Changes in the mouse ovarian surface epithelium with age and ovulation number

被引：31

作者：

Clow, OL ^{[1
]}

Hurst, PR ^{[1
]}

Fleming, JS ^{[1
]}

机构：

[1] Univ Otago, Sch Med Sci, Dept Anat & Struct Biol, Dunedin, New Zealand

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2002年 / 191卷 / 01期

关键词：

ovary; surface epithelium; mouse; scanning electron microscopy; cyst;

D O I：

10.1016/S0303-7207(02)00061-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cell biology of ovarian surface epithelium (OSE) was studied in mice of varying age and lifetime total Ovulation number (OV#), to determine the relative importance of these factors in control of OSE proliferation and development of invaginations and cysts. Ovaries from Swiss Webster mice (total OV# median: range [n mice]) were collected at 4 weeks of age (Prepubertal; 0[9]), from 3-month virgins (113: 11-235 [55]), from 12-month old breeders (217: 97-386 [21]) and from 8-month virgin mice, housed in split cages alongside a male, to induce continuous oestrous cycles (629: 456-908 [16]). Scanning electron microscopy revealed cuboidal and squamous cells in OSE from all ages. Higher total OV# markedly increased the rate of OSE invagination and layering. Histology showed the incidence of cysts, which had the appearance of benign serous cystadenomata, increased with age rather than total OV#. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：105 / 111

页数：7

共 25 条

[11] Industrial Genotoxicology Group collaborative trial to investigate cell cycle parameters in human lymphocyte cytogenetics studies [J].

Henderson, L ;

Jones, E ;

Brooks, T ;

Chetelat, A ;

Ciliutti, P ;

Freemantle, M ;

Howard, CA ;

Mackay, J ;

Phillips, B ;

Riley, S ;

Roberts, C ;

Wotton, AK ;

vandeWaart, EJ .

MUTAGENESIS, 1997, 12 (03) :163-167

[12]

Hogan B., 1986, MANIPULATING MOUSE E

[13]

Ishikawa H, 1996, J REPROD FERTIL, V108, P167, DOI 10.1530/jrf.0.1080167

[14] PROMOTION OF THE WHITTEN EFFECT IN FEMALE MICE BY SYNTHETIC ANALOGS OF MALE URINARY CONSTITUENTS [J].

JEMIOLO, B ;

HARVEY, S ;

NOVOTNY, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (12) :4576-4579

[15] OVULATION, OVULATION INDUCTION AND OVARIAN-CARCINOMA [J].

LAND, JA .

BAILLIERES CLINICAL OBSTETRICS AND GYNAECOLOGY, 1993, 7 (02) :455-472

[16] EPITHELIAL OVARIAN-CANCER - A CYTOKINE PROPELLED DISEASE [J].

MALIK, S ;

BALKWILL, F .

BRITISH JOURNAL OF CANCER, 1991, 64 (04) :617-620

[17] SCANNING ELECTRON-MICROSCOPIC STUDY OF LUTEO-FOLLICULAR COMPLEX .2. EVENTS LEADING TO OVULATION [J].

MOTTA, P ;

VANBLERKOM, J .

AMERICAN JOURNAL OF ANATOMY, 1975, 143 (02) :241-263

[18] METHODS FOR THE ANALYSIS OF CELLULAR KINETICS IN PHA-STIMULATED BLOOD-LYMPHOCYTES USING BRDU INCORPORATION - A COMPARATIVE-STUDY [J].

PALMA, V ;

TUDON, H ;

BUENTELLO, L ;

NAVA, S ;

OSTROSKY, P ;

SALAMANCA, F .

MUTATION RESEARCH, 1993, 286 (02) :267-273

[19] Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone [J].

Risch, HA .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (23) :1774-1786

[20]

Russell P., 1994, BLAUSTEINS PATHOLOGY, P705

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