Changes in the mouse ovarian surface epithelium with age and ovulation number

被引：31

作者：

Clow, OL ^{[1
]}

Hurst, PR ^{[1
]}

Fleming, JS ^{[1
]}

机构：

[1] Univ Otago, Sch Med Sci, Dept Anat & Struct Biol, Dunedin, New Zealand

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2002年 / 191卷 / 01期

关键词：

ovary; surface epithelium; mouse; scanning electron microscopy; cyst;

D O I：

10.1016/S0303-7207(02)00061-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cell biology of ovarian surface epithelium (OSE) was studied in mice of varying age and lifetime total Ovulation number (OV#), to determine the relative importance of these factors in control of OSE proliferation and development of invaginations and cysts. Ovaries from Swiss Webster mice (total OV# median: range [n mice]) were collected at 4 weeks of age (Prepubertal; 0[9]), from 3-month virgins (113: 11-235 [55]), from 12-month old breeders (217: 97-386 [21]) and from 8-month virgin mice, housed in split cages alongside a male, to induce continuous oestrous cycles (629: 456-908 [16]). Scanning electron microscopy revealed cuboidal and squamous cells in OSE from all ages. Higher total OV# markedly increased the rate of OSE invagination and layering. Histology showed the incidence of cysts, which had the appearance of benign serous cystadenomata, increased with age rather than total OV#. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：105 / 111

页数：7

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