BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice

被引：82

作者：

Yuhki, M

Yamada, M ^{[1
]}

Kawano, M

Iwasato, T

Itohara, S

Yoshida, H

Ogawa, M

Mishina, Y

机构：

[1] RIKEN, Brain Sci Inst, Lab Cell Culture Dev, Saitama 3510198, Japan

[2] RIKEN, Brain Sci Inst, Mol Neuropathol Grp, Saitama 3510198, Japan

[3] RIKEN, Brain Sci Inst, Lab Behav Genet, Saitama 3510198, Japan

[4] Nara Inst Sci & Technol, Div Gene Funct Anim, Nara 6300192, Japan

[5] RIKEN, Res Ctr Allergy & Immunol, Immune Syst Dev Grp, Kanagawa 2300045, Japan

[6] NIEHS, Reprod & Dev Toxicol Lab, Res Triangle Pk, NC 27709 USA

来源：

DEVELOPMENT | 2004年 / 131卷 / 08期

关键词：

bone morphogenetic protein; type; 1; receptor; hair follicle cycling; mouse;

D O I：

10.1242/dev.01079

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interactions between ectodermal and mesenchymal extracellular signaling pathways regulate hair follicle (HF) morphogenesis and hair cycling. Bone morphogenetic proteins (BMPs) are known to be important in hair follicle development by affecting the local cell fate modulation. To study the role of BNIP signaling in the HF, we disrupted Bmpr1a, which encodes the BMP receptor type IA (BMPR1A) in an HF cell-specific manner, using the Cre/loxP system. We found that the differentiation of inner root sheath, but not outer root sheath, was severely impaired in mutant mice. The number of HFs was reduced in the dermis and subcutaneous tissue, and cycling epithelial cells were reduced in mutant mice HFs. Our results strongly suggest that BMPR1A signaling is essential for inner root sheath differentiation and is indispensable for HF renewal in adult skin.

引用

页码：1825 / 1833

页数：9