The phenotypic spectrum of progressive supranuclear palsy

被引：67

作者：

Respondek, G. ^{[1
,2
]}

Hoeglinger, G. U. ^{[1
,2
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, D-81675 Munich, Germany

[2] DZNE, D-81677 Munich, Germany

来源：

PARKINSONISM & RELATED DISORDERS | 2016年 / 22卷

关键词：

Phenotypes; Progressive supranuclear palsy PSP; Tauopathy; RICHARDSON-OLSZEWSKI-SYNDROME; CLINICAL PHENOTYPE; PURE AKINESIA; PSP; DEGENERATION; DIAGNOSIS; FEATURES; APRAXIA; DISEASE; SPEECH;

D O I：

10.1016/j.parkreldis.2015.09.041

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Traditionally, the clinical picture of progressive supranuclear palsy (PSP) was defined by early postural instability with falls, supranuclear vertical gaze palsy, symmetric akinesia and rigidity, frontal and subcortical dementia, and pseudobulbar palsy, leading to death after a mean disease duration of approximately six years. A definite diagnosis of PSP depends on neuropathological confirmation. In recent years, clinico-pathological studies have drawn attention to various "atypical" clinical manifestations of PSP. In these, a clinical diagnosis of PSP is delayed or never accomplished. Comprehensive understanding of the natural history of PSP is required to permit an early and accurate diagnosis. Based on current evidence, this review provides an update on the clinical spectrum of PSP. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：S34 / S36

页数：3

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