Stem cell transplant in MF: it's time to personalize

被引：18

作者：

Passamonti, Francesco ^{[1
]}

机构：

[1] Univ Insubria, Varese Va, Italy

来源：

BLOOD | 2019年 / 133卷 / 20期

关键词：

PROGNOSTIC MODEL; PREDICT SURVIVAL;

D O I：

10.1182/blood-2019-03-900860

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this issue of Blood, Gagelmann et al(1) describe an integrated clinical-molecular prognostic model (Myelofibrosis Transplant Scoring System [MTSS]) to predict outcome post stem cell transplant (SCT) in myelofibrosis (MF). MF is a clonal stem cell neoplasm with heterogeneous clinical phenotypes and well-defined driver mutations found in similar to 90% of the cases. (2) Despite the introduction of JAK inhibitors, (3) MF still remains an incurable disease with a median survival of 4 to 5 years. SCT is an option for MF patients, (4) but, because of the very high risk of mortality, the patient selection is very critical.

引用

页码：2118 / +

页数：5

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