Receptor Research Prize 2006 Lecture - The T-cell antigen receptor: A logical response to an unknown ligand

被引：10
作者：
Palmer, Ed
机构：
[1] Univ Basel Hosp, Res Dept, CH-4031 Basel, Switzerland
[2] Univ Basel Hosp, Dept Nephrol, Lab Transplantat Immunol, CH-4031 Basel, Switzerland
来源：
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION | 2006年 / 26卷 / 5-6期
关键词：
T-cell receptor; T lymphocytes; antigen recognition; self-reactive T cells; kinetic proofreading;
D O I：
10.1080/10799890600919094
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The immune system can be roughly divided into innate and adaptive compartments. The adaptive compartment includes the B and T lymphocytes, whose antigen receptors are generated by recombination of gene segments. The consequence is that the creation of self-reactive lymphocytes is unavoidable. For the host to remain viable, the immune system has evolved a strategy for removing autoimmune lymphocytes during development. This review discusses how T lymphocytes are generated, how they recognize antigens, and how their antigen receptor directs the removal of self-reactive T cells.
引用
收藏
页码：367 / 378
页数：12
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