The evaluation of measurement uncertainty from method validation studies - Part 2: The practical application of a laboratory protocol

被引：42

作者：

Barwick, VJ ^{[1
]}

Ellison, SLR ^{[1
]}

Rafferty, MJQ ^{[1
]}

Gill, RS ^{[1
]}

机构：

[1] Lab Govt Chemist, Teddington TW11 0LY, Middx, England

来源：

ACCREDITATION AND QUALITY ASSURANCE | 2000年 / 5卷 / 03期

关键词：

measurement uncertainty; method validation; precision; trueness; ruggedness; high performance liquid chromatography;

D O I：

10.1007/s007690050022

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A protocol has been developed illustrating the link between validation experiments and measurement uncertainty evaluation. The application of the protocol is illustrated with reference to a method for the determination of three markers (CI solvent red 24, quinizarin and CI solvent yellow 124) in fuel oil samples. The method requires the extraction of the markers from the sample matrix by solid phase extraction followed by quantification by high performance liquid chromatography (HPLC) with diode array detection. The uncertainties for the determination of the markers were evaluated using data from precision and trueness studies using representative sample matrices spiked at a range of concentrations, and from ruggedness studies of the extraction and HPLC stages.

引用

页码：104 / 113

页数：10

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