Anti-inflammatory influences on behavioral, but not cortisol, responses during maternal separation

被引：31
作者：
Perkeybile, Allison M. [1 ]
Schiml-Webb, Patricia A. [1 ]
O'Brien, Erin [1 ]
Deak, Terrence [2 ]
Hennessy, Michael B. [1 ]
机构：
[1] Wright State Univ, Dept Psychol, Dayton, OH 45435 USA
[2] SUNY Binghamton, Behav Neurosci Program, Dept Psychol, Binghamton, NY 13902 USA
来源：
PSYCHONEUROENDOCRINOLOGY | 2009年 / 34卷 / 07期
关键词：
Sickness behavior; Maternal separation; Social isolation; Hypothalamic-pituitary-adrenal; Anti-inflammatory; Acute phase response; Attachment; Interleukin-10; Alpha-MSH; Guinea pig; MELANOCYTE-STIMULATING HORMONE; CORTICOTROPIN-RELEASING-FACTOR; GUINEA-PIG PUPS; INDUCED SICKNESS BEHAVIORS; ACUTE-PHASE RESPONSE; ALPHA-MSH; MAJOR DEPRESSION; SOCIAL SEPARATION; PASSIVE RESPONSES; ADRENAL-RESPONSE;
D O I：
10.1016/j.psyneuen.2009.02.014
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The present study examined the effect of anti-inflammatory agents on the behavioral and plasma cortisol responses of guinea pig pups during isolation in a novel environment. In Experiment 1, intracerebroventricular (ICV) administration of interleukin-10 (IL-10), across a range of doses, significantly reduced passive behaviors of isolated pups. In Experiment 2, neither ICV IL-10 nor alpha-metanocyte stimulating hormone affected the plasma cortisol response to the separation procedure. These results provide further evidence that the passive behaviors of isolated guinea pig pups are mediated by proinflammatory cytokines and indicate that cytokines do not affect behavior indirectly by means of an action on hypothalamic-pituitary-ad renal activity. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1101 / 1108
页数：8
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