Advances in structural genomics

被引：109
作者：
Teichmann, SA
Chothia, C
Gerstein, M
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
[2] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1999年 / 9卷 / 03期
关键词：
D O I：
10.1016/S0959-440X(99)80053-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New computational techniques have allowed protein folds to be assigned to all or parts of between a quarter (Caenorhabditis elegans) and a half (Mycoplasma genitalium) of the individual protein sequences in different genomes. These assignments give a new perspective on domain structures, gene duplications, protein families and protein folds in genome sequences.
引用
收藏
页码：390 / 399
页数：10
相关论文
共 60 条
[51]  
SCHARF M, 1994, P 2 INT C INT SYST M, P348
[52]   The Argonne Structural Genomics Workshop: Lamaze class for the birth of a new science [J].
Shapiro, L ;
Lima, CD .
STRUCTURE, 1998, 6 (03) :265-267
[53]   DETECTION OF NATIVE-LIKE MODELS FOR AMINO-ACID-SEQUENCES OF UNKNOWN 3-DIMENSIONAL STRUCTURE IN A DATA-BASE OF KNOWN PROTEIN CONFORMATIONS [J].
SIPPL, MJ ;
WEITCKUS, S .
PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1992, 13 (03) :258-271
[54]   IDENTIFICATION OF COMMON MOLECULAR SUBSEQUENCES [J].
SMITH, TF ;
WATERMAN, MS .
JOURNAL OF MOLECULAR BIOLOGY, 1981, 147 (01) :195-197
[55]   Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements [J].
Teichmann, SA ;
Park, J ;
Chothia, C .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14658-14663
[56]   Class-directed structure determination: Foundation for a protein structure initiative [J].
Terwilliger, TC ;
Waldo, G ;
Peat, TS ;
Newman, JM ;
Chu, K ;
Berendzen, J .
PROTEIN SCIENCE, 1998, 7 (09) :1851-1856
[57]   Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms [J].
Wallin, E ;
von Heijne, G .
PROTEIN SCIENCE, 1998, 7 (04) :1029-1038
[58]  
Wolf YI, 1999, GENOME RES, V9, P17
[59]  
Wootton JC, 1996, METHOD ENZYMOL, V266, P554
[60]   Structure-based assignment of the biochemical function of a hypothetical protein: A test case of structural genomics [J].
Zarembinski, TI ;
Hung, LW ;
Mueller-Dieckmann, HJ ;
Kim, KK ;
Yokota, H ;
Kim, R ;
Kim, SH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15189-15193
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