Mimicking phosphorylation within the microtubule-binding repeat domain of tau abolishes microtubule binding and PHF formation

被引：0
|
作者：
Hascher, A [1 ]
Biernat, J [1 ]
Mandelkow, EM [1 ]
机构：
[1] Max Planck Soc, Hamburg, Germany
来源：
NEUROBIOLOGY OF AGING | 2004年 / 25卷
关键词：
D O I：
10.1016/S0197-4580(04)81417-9
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
引用
收藏
页码：S430 / S431
页数：2
相关论文
共 50 条
  • [21] PHOSPHORYLATION OF SER(262) STRONGLY REDUCES BINDING OF TAU-PROTEIN TO MICROTUBULES - DISTINCTION BETWEEN PHF-LIKE IMMUNOREACTIVITY AND MICROTUBULE-BINDING
    BIERNAT, J
    GUSTKE, N
    DREWES, G
    MANDELKOW, EM
    MANDELKOW, E
    NEURON, 1993, 11 (01) : 153 - 163
  • [22] Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain
    Hattori, Masaki
    Sugino, Etsuko
    Minoura, Katsuhiko
    In, Yasuko
    Sumida, Miho
    Taniguchi, Taizo
    Tomoo, Koji
    Ishida, Toshimasa
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 374 (01) : 158 - 163
  • [23] Phosphorylation modulates the alpha-helical structure and polymerization of a peptide from the third tau microtubule-binding repeat
    Mendieta, J
    Fuertes, MA
    Kunjishapatham, R
    Santa-María, I
    Moreno, FJ
    Alonso, C
    Gago, F
    Muñoz, V
    Avila, J
    Hernández, F
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2005, 1721 (1-3): : 16 - 26
  • [24] Deamidation and isoaspartate formation in smeared tau in paired helical filaments: Unusual properties of the microtubule-binding domain of tau
    J Biol Chem, 2-11 (7368-7378):
  • [25] Structural characterization of the microtubule-binding domain of doublecortin
    Guenther, B
    Ghetti, B
    Benson, M
    MOLECULAR BIOLOGY OF THE CELL, 2002, 13 : 188A - 188A
  • [26] Tau: More than a microtubule-binding protein in neurons
    Alonso, Alejandra del Carmen
    El Idrissi, Abdeslem
    Candia, Robert
    Morozova, Viktoriya
    Kleiman, Frida Esther
    CYTOSKELETON, 2024, 81 (01) : 71 - 77
  • [27] Structure of the Microtubule-Binding Domain of Flagellar Dynein
    Kato, Yusuke S.
    Yagi, Toshiki
    Harris, Sarah A.
    Ohki, Shin-ya
    Yura, Kei
    Shimizu, Youske
    Honda, Shinya
    Kamiya, Ritsu
    Burgess, Stan A.
    Tanokura, Masaru
    STRUCTURE, 2014, 22 (11) : 1628 - 1638
  • [28] Heterologous expression and fibrillary characterization of the microtubule-binding domain of tau associated with tauopathies
    Peng, Chong
    Wei, Wei
    Zhang, Huitu
    Wang, Ying
    Chang, Baogen
    Zhao, Wenping
    Jia, Longgang
    Li, Li
    Lu, Fuping
    Liu, Fufeng
    MOLECULAR BIOLOGY REPORTS, 2024, 51 (01)
  • [29] The Effect of a ΔK280 Mutation on the Unfolded State of a Microtubule-Binding Repeat in Tau
    Huang, Austin
    Stultz, Collin M.
    PLOS COMPUTATIONAL BIOLOGY, 2008, 4 (08)
  • [30] Conformational transition state is responsible for assembly of microtubule-binding domain of tau protein
    Hiraoka, S
    Yao, TM
    Minoura, K
    Tomoo, K
    Sumida, M
    Taniguchi, T
    Ishida, T
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 315 (03) : 659 - 663
12345