Expression, regulation and function of miR-495 in healthy and tumor tissues

被引：44

作者：

Chen, Hongli ^{[1
]}

Wang, Xiaman ^{[1
]}

Bai, Ju ^{[1
]}

He, Aili ^{[1
,2
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Hematol, 157 West Five Rd, Xian 710004, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Natl Local Joint Engn Res Ctr Biodiagnost & Bioth, Xian 710004, Shaanxi, Peoples R China

来源：

ONCOLOGY LETTERS | 2017年 / 13卷 / 04期

关键词：

miRNA-495; 14q32.31; cluster; expression regulation; function; GASTRIC-CANCER CELLS; DOWN-REGULATION; STEM-CELLS; MICRORNA EXPRESSION; GALLBLADDER CANCER; PANCREATIC-CANCER; GENE-EXPRESSION; CROHNS-DISEASE; ADULT PATIENTS; DIFFERENTIATION;

D O I：

10.3892/ol.2017.5727

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNA-495 (miR-495) is a small non-coding RNA encoded by a gene located on chromosome 14 (14q32.31). Its expression is regulated by the transcription factors EF12 and EF47, in addition to promoter methylation status and the fusion oncoprotein mixed-lineage leukemia-AF9. Previous studies suggest that miR-495 is involved in various developmental, immunological and inflammatory processes in healthy tissue, and in the proliferation, invasion, metastasis and drug resistance of cancer cells. The role miR-495 serves in tumors is controversial. miR-495 primarily functions as a tumor suppressor; however, in a number of cases it acts as an oncogene. miR-495 has potential applications as a diagnostic and prognostic marker, and as a therapeutic target for genetic and pharmacological manipulation in the treatment of various diseases.

引用

页码：2021 / 2026

页数：6

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