Association Between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging

被引：5

作者：

Krell-Roesch, Janina ^{[1
,2
]}

Syrjanen, Jeremy A. ^{[1
]}

Mielke, Michelle M. ^{[1
,3
]}

Christianson, Teresa J. ^{[1
]}

Kremers, Walter K. ^{[1
]}

Machulda, Mary M. ^{[4
]}

Knopman, David S. ^{[3
]}

Petersen, Ronald C. ^{[1
,3
]}

Vassilaki, Maria ^{[1
]}

Geda, Yonas E. ^{[5
]}

机构：

[1] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[2] Karlsruhe Inst Technol, Inst Sports & Sports Sci, Karlsruhe, Germany

[3] Mayo Clin, Dept Neurol, Rochester, MN USA

[4] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA

[5] Barrow Neurol Inst, Dept Neurol, Phoenix, AZ 85013 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2020年 / 78卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Anxiety; depression; functional performance; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; DEMENTIA; PREVALENCE; APATHY; MCI;

D O I：

10.3233/JAD-200764

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the associations between baseline neuropsychiatric symptoms (NPS) and longitudinal changes in functional performance among 5,394 non-demented individuals aged >= 50 years (2,729 males; median age 74.2 years; 4,716 cognitively unimpaired, 678 mild cognitive impairment). After adjusting for age, sex, education, and medical comorbidities, NPS assessed by the Neuropsychiatric Inventory Questionnaire, clinical depression (Beck Depression Inventory score >= 13) and anxiety (Beck Anxiety Inventory score >= 10) were significantly associated with an increase in the Functional Activities Questionnaire score, indicating functional decline over time. This association may vary depending on the degree of cognitive impairment at baseline.

引用

页码：911 / 917

页数：7

共 22 条

[1]

[Anonymous], BECK ANXIETY INVENTO, DOI DOI 10.1176/AJP.147.2.190

[2]

Beck AT, 2001, MANUAL BECK DEPRESSI

[3] Executive dysfunction and apathy predict functional impairment in Alzheimer disease [J].

Boyle, PA ;

Malloy, PF ;

Salloway, S ;

Cahn-Weiner, DA ;

Cohen, R ;

Cummings, JL .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2003, 11 (02) :214-221

[4] Functional Impairment in Elderly Patients With Mild Cognitive Impairment and Mild Alzheimer Disease [J].

Brown, Patrick J. ;

Devanand, D. P. ;

Liu, Xinhua ;

Caccappolo, Elise .

ARCHIVES OF GENERAL PSYCHIATRY, 2011, 68 (06) :617-626

[5] Cognitive and Neuropsychiatric Correlates of Functional Impairment Across the Continuum of No Cognitive Impairment to Dementia [J].

Burton, Rachel L. ;

O'Connell, Megan E. ;

Morgan, Debra G. .

ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 2018, 33 (07) :795-807

[6] Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults [J].

Creese, Byron ;

Brooker, Helen ;

Ismail, Zahinoor ;

Wesnes, Keith A. ;

Hampshire, Adam ;

Khan, Zunera ;

Megalogeni, Maria ;

Corbett, Anne ;

Aarsland, Dag ;

Ballard, Clive .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2019, 27 (08) :823-834

[7]

D'Onofrio G, 2012, CURR ALZHEIMER RES, V9, P759

[8] Neuropsychiatric Symptoms in Alzheimer's Disease Are the Main Determinants of Functional Impairment in Advanced Everyday Activities [J].

Delgado, Carolina ;

Vergara, Rodrigo C. ;

Martinez, Melissa ;

Musa, Gada ;

Henriquez, Fernando ;

Slachevsky, Andrea .

JOURNAL OF ALZHEIMERS DISEASE, 2019, 67 (01) :381-392

[9] Daily Function as Predictor of Dementia in Cognitive Impairment, No Dementia (CIND) and Mild Cognitive Impairment (MCI): An 8-Year Follow-Up in the ILSA Study [J].

Di Carlo, Antonio ;

Baldereschi, Marzia ;

Lamassa, Maria ;

Bovis, Francesca ;

Inzitari, Marco ;

Solfrizzi, Vincenzo ;

Panza, Francesco ;

Galluzzo, Lucia ;

Scafato, Emanuele ;

Inzitari, Domenico .

JOURNAL OF ALZHEIMERS DISEASE, 2016, 53 (02) :505-515

[10] Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging - Population-based study [J].

Geda, Yonas E. ;

Roberts, Rosebud O. ;

Knopman, David S. ;

Petersen, Ronald C. ;

Christianson, Teresa J. H. ;

Pankratz, Vernon S. ;

Smith, Glenn E. ;

Boeve, Bradley F. ;

Ivnik, Robert J. ;

Tangalos, Eric G. ;

Rocca, Walter A. .

ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (10) :1193-1198

← 1 2 3 →