miR-425 inhibits melanoma metastasis through repression of PI3K-Akt pathway by targeting IGF-1

被引：43

作者：

Liu, Pei ^{[1
]}

Hu, Yaotian ^{[2
]}

Ma, Ling ^{[1
]}

Du, Min ^{[1
]}

Xia, Lin ^{[1
]}

Hu, Zhensheng ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Plast Surg, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Qilu Hosp, Dept Gen Surg, Jinan 250012, Shandong, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2015年 / 75卷

关键词：

miR-425; IGF-1; Melanoma; Metastasis; GROWTH-FACTOR SYSTEM; MICRORNA EXPRESSION; MALIGNANT-MELANOMA; FACTOR-I; CANCER; SUPPRESSES; MECHANISMS; PROTEIN;

D O I：

10.1016/j.biopha.2015.08.010

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

miR-425 is a potential tumor suppressor in cancer, but its role in melanoma is still unknown. We aim to investigate miR-425 expression in melanoma tissues and cell lines. Next, cell proliferation, cell cycle, apoptosis and metastasis will be studied using lentivirus-mediated gain-of-function studies. The predicted results are stable miR-425 inhibits cell proliferation and metastasis and induced cell apoptosis. It is predicted that IGF-1 is a potential target gene of miR-495 by bioinformatics analysis. Then luciferase assay analysis identifies IGF-1 as a new direct target gene of miR-425 and miR-425 inhibits melanoma cancer progression via IGF-1. Collectively, our findings suggested that miR-425 may function as a tumor suppressor in melanoma by targeting IGF-1. (C) 2015 Elsevier Masson SAS. All rights reserved.

引用

页码：51 / 57

页数：7

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