Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities

被引：446

作者：

Wen, Yankai ^{[1
]}

Lambrecht, Joeri ^{[2
]}

Ju, Cynthia ^{[1
]}

Tacke, Frank ^{[2
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Anesthesiol, Houston, TX 77030 USA

[2] Charite Univ Med Berlin, Dept Hepatol & Gastroenterol, Berlin, Germany

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2021年 / 18卷 / 01期

关键词：

Kupffer cells; monocyte-derived macrophages; liver inflammation; liver fibrosis; liver cancer; MONOCYTE-DERIVED MACROPHAGES; TISSUE-RESIDENT MACROPHAGES; NLRP3 INFLAMMASOME ACTIVATION; ISCHEMIA-REPERFUSION INJURY; PREDICTS POOR-PROGNOSIS; KUPFFER CELLS MEDIATE; KAPPA-B ACTIVATION; NONALCOHOLIC STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA; STELLATE CELLS;

D O I：

10.1038/s41423-020-00558-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Macrophages, which are key cellular components of the liver, have emerged as essential players in the maintenance of hepatic homeostasis and in injury and repair processes in acute and chronic liver diseases. Upon liver injury, resident Kupffer cells (KCs) sense disturbances in homeostasis, interact with hepatic cell populations and release chemokines to recruit circulating leukocytes, including monocytes, which subsequently differentiate into monocyte-derived macrophages (MoM phi s) in the liver. Both KCs and MoM phi s contribute to both the progression and resolution of tissue inflammation and injury in various liver diseases. The diversity of hepatic macrophage subsets and their plasticity explain their different functional responses in distinct liver diseases. In this review, we highlight novel findings regarding the origins and functions of hepatic macrophages and discuss the potential of targeting macrophages as a therapeutic strategy for liver disease.

引用

页码：45 / 56

页数：12

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