BAR the door: Cancer suppression by amphiphysin-like genes

被引：54
作者：
Prendergast, George C. [1 ,2 ]
Muller, Alexander J. [1 ,2 ]
Ramalingam, Arivudanambi [1 ]
Chang, Mee Young [1 ]
机构：
[1] Lankenou Inst Med Res, Wynnewood, PA USA
[2] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2009年 / 1795卷 / 01期
关键词：
Tumor suppressor; Modifier; Lung cancer; Vesicle trafficking; Indoleamine 2,3-dioxygenase; c-myc; Ras; Rho; C-MYC; TUMOR-SUPPRESSOR; INDOLEAMINE 2,3-DIOXYGENASE; PROTEIN-INTERACTION; CELL-PROLIFERATION; SH3; DOMAIN; FARNESYLTRANSFERASE INHIBITORS; ACTIN CYTOSKELETON; CRYSTAL-STRUCTURE; BIN1; ABLATION;
D O I：
10.1016/j.bbcan.2008.09.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The evolutionarily conserved amphiphysin-like genes Bin1 and Bin3 function in membrane and actin dynamics, cell polarity, and stress signaling. Recent genetic studies in mice discriminate non-essential roles in endocytic processes commonly ascribed to amphiphysins from essential roles in cancer suppression. Bin I acts in default pathways of apoptosis and senescence that are triggered by the Myc and Raf oncogenes in primary cells, and Bin1 gene products display a 'moonlighting function' in the nucleus where a variety of other 'endocytic' proteins are also found. Together, genetic investigations in yeast, flies, and mice suggest that amphiphysin-like adapter proteins may suppress cancer by helping integrate cell polarity signals generated by actin and vesicle dynamics with central regulators of cell cycle arrest, apoptosis, and immune surveillance. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：25 / 36
页数：12
相关论文
共 148 条
[1]   Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis [J].
Anggono, Victor ;
Robinson, Phillip J. .
JOURNAL OF NEUROCHEMISTRY, 2007, 102 (03) :931-943
[2]   Antiamphiphysin antibodies are associated with various paraneoplastic neurological syndromes and tumors [J].
Antoine, JC ;
Absi, L ;
Honnorat, J ;
Boulesteix, JM ;
de Brouker, T ;
Vial, C ;
Butler, M ;
De Camilli, P ;
Michel, D .
ARCHIVES OF NEUROLOGY, 1999, 56 (02) :172-177
[3]   LKB1 tumor suppressor protein: PARtaker in cell polarity [J].
Baas, AF ;
Smit, L ;
Clevers, H .
TRENDS IN CELL BIOLOGY, 2004, 14 (06) :312-319
[4]  
Balguerie A, 1999, J CELL SCI, V112, P2529
[5]   ALTERATION OF A YEAST SH3 PROTEIN LEADS TO CONDITIONAL VIABILITY WITH DEFECTS IN CYTOSKELETAL AND BUDDING PATTERNS [J].
BAUER, F ;
URDACI, M ;
AIGLE, M ;
CROUZET, M .
MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (08) :5070-5084
[6]   Cytoplasmic transport of Stat3 by receptor-mediated endocytosis [J].
Bild, AH ;
Turkson, J ;
Jove, R .
EMBO JOURNAL, 2002, 21 (13) :3255-3263
[7]   The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q [J].
Borkhardt, A ;
Bojesen, S ;
Haas, OA ;
Fuchs, U ;
Bartelheimer, D ;
Loncarevic, IF ;
Bohle, RM ;
Harbott, J ;
Repp, R ;
Jaeger, U ;
Viehmann, S ;
Henn, T ;
Korth, P ;
Scharr, D ;
Lampert, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) :9168-9173
[8]   Genetic and functional relationship between Rvsp, myosin and actin in Saccharomyces cerevisiae [J].
Breton, AM ;
Aigle, M .
CURRENT GENETICS, 1998, 34 (04) :280-286
[9]   Rvs161p interacts with Fus2p to promote cell fusion in Saccharomyces cerevisiae [J].
Brizzio, V ;
Gammie, AE ;
Rose, MD .
JOURNAL OF CELL BIOLOGY, 1998, 141 (03) :567-584
[10]   Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of Ranvier in brain and around T tubules in skeletal muscle [J].
Butler, MH ;
David, C ;
Ochoa, GC ;
Freyberg, Z ;
Daniell, L ;
Grabs, D ;
Cremona, O ;
DeCamilli, P .
JOURNAL OF CELL BIOLOGY, 1997, 137 (06) :1355-1367
12345678910