Pharmacokinetic profile of spectinomycin in rats

被引：5
|
作者：
Madhura, D. B. [1 ]
Lee, R. [2 ]
Meibohm, B. [1 ]
机构：
[1] Univ Tennessee, Hlth Sci Ctr, Dept Pharmaceut Sci, Memphis, TN 38163 USA
[2] St Jude Childrens Res Hosp, Dept Chem Biol & Therapeut, Memphis, TN 38105 USA
来源：
PHARMAZIE | 2013年 / 68卷 / 08期
基金：
美国国家卫生研究院;
关键词：
INHIBITION; PARAMETERS;
D O I：
10.1691/ph.2013.3501
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Following intravenous (IV) administration, the pharmacokinetics of spectinomycin in rats was found to be on par with its profile in other mammalian species including humans with respect to its overall excretion and half-life at effective concentrations. This study, however, indicates that a small fraction of the spectinomycin dose is retained in peripheral tissues for a prolonged period of time at low concentrations.
引用
收藏
页码：675 / 676
页数：2
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