Irregular sleep and all-cause mortality: A large prospective cohort study

被引：14

作者：

Omichi, Chie ^{[1
,2
,3
]}

Koyama, Teruhide ^{[1
,23
]}

Kadotani, Hiroshi ^{[2
]}

Ozaki, Etsuko ^{[1
]}

Tomida, Satomi ^{[1
,4
]}

Yoshida, Tamami ^{[1
]}

Otonari, Jun ^{[5
,6
]}

Ikezaki, Hiroaki ^{[7
,8
]}

Hara, Megumi ^{[9
]}

Tanaka, Keitaro ^{[9
]}

Tamura, Takashi ^{[10
]}

Nagayoshi, Mako ^{[10
]}

Okada, Rieko ^{[10
]}

Kubo, Yoko ^{[10
]}

Oze, Isao ^{[11
]}

Matsuo, Keitaro ^{[11
,12
]}

Nakamura, Yohko ^{[13
]}

Kusakabe, Miho ^{[13
]}

Ibusuki, Rie ^{[14
]}

Shibuya, Kenichi ^{[14
,15
]}

Suzuki, Sadao ^{[16
]}

Watanabe, Miki ^{[16
,17
]}

Kuriki, Kiyonori ^{[18
,19
]}

Takashima, Naoyuki ^{[20
]}

Kadota, Aya ^{[20
]}

Katsuura-Kamano, Sakurako ^{[21
]}

Arisawa, Kokichi ^{[21
]}

Takeuchi, Kenji ^{[10
,22
]}

Wakai, Kenji ^{[10
]}

机构：

[1] Kyoto Prefectural Univ Med, Dept Epidemiol Community Hlth & Med, 465 Kajii Cho,Kamigyo Ku, Kyoto 6028566, Japan

[2] Shiga Univ Med Sci, Dept Psychiat, Tsukinowa Cho, Otsu 5202192, Japan

[3] Osaka Med & Pharmaceut Univ, Dept Hyg & Publ Hlth, 2-7,daigaku Machi, Takatsuki 5698686, Japan

[4] Kyoto Prefectural Univ Med, Dept Endocrine & Breast Surg, 465 Kajii Cho,Kamigyo Ku, Kyoto 6028566, Japan

[5] Kyushu Univ, Grad Sch Med Sci, Dept Psychosomat Med, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan

[6] Int Univ Hlth & Welf Narita Hosp, Dept Psychosomat Med, 852 Hatakeda, Chiba 2860124, Japan

[7] Kyushu Univ Hosp, Dept Gen Internal Med, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan

[8] Kyushu Univ, Dept Comprehens Gen Internal Med, Fac Med Sci, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan

[9] Saga Univ, Fac Med, Dept Prevent Med, 5-1-1 Nabeshima, Saga 8498501, Japan

[10] Nagoya Univ, Dept Prevent Med, Grad Sch Med, 65 Tsurumai Cho,Showa Ku, Nagoya 4668550, Japan

[11] Aichi Canc Ctr Res Inst, Div Canc Epidemiol & Prevent, 1-1 Kanokoden,Chikusa Ku, Nagoya 4648681, Japan

[12] Nagoya Univ, Div Canc Epidemiol, Grad Sch Med, 65 Tsurumai Cho,Showa Ku, Nagoya 4668550, Japan

[13] Chiba Canc Ctr Res Inst, Canc Prevent Ctr, 666-2 Nitona Cho,Chuo Ku, Chiba 2608717, Japan

[14] Kagoshima Univ, Dept Int Isl & Community Med, Grad Sch Med & Dent Sci, 8-35-1 Sakuragaoka, Kagoshima 8908544, Japan

[15] Kagoshima Prefectural Oshima Hosp, Dept Emergency, 18-1 Nazemanazucho, Kagoshima 8940015, Japan

[16] Nagoya City Univ, Dept Publ Hlth, Grad Sch Med Sci, 1 Kawasumi,Mizuho Cho,Mizuho Ku, Nagoya 4678601, Japan

[17] Aichi Univ Educ, Dept Sch Hlth Sci, 1 Hirosawa,Igaya Cho, Kariya, Aichi 4488542, Japan

[18] Univ Shizuoka, Sch Food & Nutr Sci, Div Nutr Sci, Lab Publ Hlth, 52-1 Yada,Suruga Ku, Shizuoka 4228526, Japan

[19] Shiga Univ Med Sci, Dept Publ Hlth, Otsu 5202192, Japan

[20] Kindai Univ, Dept Publ Hlth, Fac Med, 377-2 Osaka Sayama, Osaka 5898511, Japan

[21] Tokushima Univ, Inst Biomed Sci, Dept Prevent Med, Grad Sch, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan

[22] Tohoku Univ, Dept Int & Community Oral Hlth, Grad Sch Dent, 4-1 Seiryo-machi, Aoba-ku, Sendai 9808575, Japan

[23] Kyoto Prefectural Univ Med, Dept Epidemiol Community Hlth & Med, 465 Kajii Cho,Kamigyo Ku, Kyoto 6028566, Japan

来源：

SLEEP HEALTH | 2022年 / 8卷 / 06期

基金：

日本学术振兴会;

关键词：

Sleep regularity; All-cause mortality; Sleep duration; MULTIINSTITUTIONAL COLLABORATIVE COHORT; METABOLIC SYNDROME; LIFE-STYLE; DURATION; METAANALYSIS; VARIABILITY; HEALTH; CONSEQUENCES; ASSOCIATIONS; RHYTHMS;

D O I：

10.1016/j.sleh.2022.08.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives: Previous studies using objective parameters have shown that irregular sleep is associated with the disease incidence, progression, or mortality. This study aimed to determine the association between subjec-tive sleep duration and sleep regularity, with mortality in a large population.Methods: Participants were from the Japan Multi-Institutional Collaborative Cohort study. We obtained infor-mation from each participant on sleep duration, sleep regularity, and demographics and overall lifestyle using self-administered questionnaires. We defined sleep regularity according to participants' subjective assessment of sleep/wake time regularity. Participants (n = 81,382, mean age: 58.1 +/- 9.1years, males: 44.2%) were classified into 6 groups according to sleep duration and sleep regularity. Hazard ratios (HR) for time-to -event of death were calculated using the Cox proportional hazards model.Results: The mean follow-up period was 9.1 years and the mean sleep duration was 6.6 h/day. Irregular sleep significantly increased the risk of all-cause mortality in all models compared with regular sleep (HR 1.30, 95% confidence interval; CI, 1.18-1.44), regardless of sleep duration. Multivariable analysis of the 6 groups by sleep pattern (sleep regularity and duration) showed irregular sleep and sleep durations of <6 h/day, 6 to <8 h/day, or >= 8 h/day were associated with a 1.2-1.5-fold increases in mortality, compared to regular sleep and sleep duration of 6 to <8 h/day.Conclusions: Our study shows an association between sleep irregularity and all-cause mortality in a large Jap-anese population. Our findings provide further confirmation of the need to consider not only sleep duration, but also the regularity aspect of sleep schedules.(c) 2022 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.

引用

页码：678 / 683

页数：6

共 40 条

[1]

Banks S, 2007, J CLIN SLEEP MED, V3, P519

[2] Beyond the mean: A systematic review on the correlates of daily intraindividual variability of sleep/wake patterns [J].