Overview of pleiotropic effects of platelet P2Y12 receptor inhibitors

被引：43

作者：

Adamski, Piotr ^{[1
]}

Kozinski, Marek ^{[1
]}

Ostrowska, Malgorzata ^{[1
]}

Fabiszak, Tomasz ^{[2
]}

Navarese, Eliano Pio ^{[2
]}

Paciorek, Przemyslaw ^{[3
]}

Grzesk, Grzegorz ^{[2
,4
]}

Kubica, Jacek ^{[2
]}

机构：

[1] Nicolaus Copernicus Univ, Dept Principles Clin Med, Coll Med, PL-85094 Bydgoszcz, Poland

[2] Nicolaus Copernicus Univ, Dept Cardiol & Internal Med, Coll Med, PL-85094 Bydgoszcz, Poland

[3] Nicolaus Copernicus Univ, Dept Emergency Med, Coll Med, PL-85094 Bydgoszcz, Poland

[4] Nicolaus Copernicus Univ, Dept Pharmacol & Therapy, Coll Med, PL-85094 Bydgoszcz, Poland

来源：

THROMBOSIS AND HAEMOSTASIS | 2014年 / 112卷 / 02期

关键词：

Clopidogrel; off-target effect; P2Y12; receptor; prasugrel; ticagrelor; ACUTE CORONARY SYNDROMES; INFLAMMATORY MARKERS; P2Y(12) RECEPTOR; ARTERY-DISEASE; DOUBLE-BLIND; ANTIPLATELET THERAPY; CLINICAL-OUTCOMES; CLOPIDOGREL; TICAGRELOR; PRASUGREL;

D O I：

10.1160/TH13-11-0915

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dual antiplatelet therapy consisting of one of the P2Y12 receptor inhibitors in conjunction with aspirin is the mainstay of treatment for patients with acute coronary syndromes (ACS) and those undergoing percutaneous coronary interventions (PCI). In recent years, multiple extra-platelet features of P2Y12 receptor antagonists have been reported in numerous clinical trials. The aim of this review is to summarise reported pleiotropic effects of clopidogrel, prasugrel, ticagrelor and other P2Y12 receptor blockers. We included observations made both in human and in animal models, together with proposed mechanisms of action for described features. If confirmed in randomised studies and properly applied to everyday practice, the observed extra-platelet actions could enable us to improve efficacy of ACS and post-PCI treatment, as well as to confine mortality and occurrence rate of cardiovascular events.

引用

页码：224 / 242

页数：19

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