Regulation of the Wnt/β-catenin pathway by redox signaling

Although it is well established that reactive oxygen species (ROS) can function as intracellular messengers, the mechanism of ROS dependent signaling is largely unknown (Rhee et al., 2005). In a recent paper in Nature Cell Biology, Funato et al. (2006) demonstrate that ROS can modulate signaling by the Wnt/ beta-catenin pathway. This work provides interesting new insight into cross-talk between redox and Wntl beta-catenin signaling in normal physiology and cancer.