Gene regulation by non-coding RNAs

被引：144

作者：

Patil, Veena S. ^{[1
]}

Zhou, Rui ^{[1
]}

Rana, Tariq M. ^{[1
,2
,3
]}

机构：

[1] Sanford Burnham Med Res Inst, Program RNA Biol, La Jolla, CA USA

[2] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Biomed Sci Grad Program, La Jolla, CA 92093 USA

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2014年 / 49卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Gene silencing; lincRNAs; miRNA; ncRNA; RNA complexes; SMALL-INTERFERING RNA; PIWI-INTERACTING RNAS; TRANS-ACTING SIRNAS; SINGLE-STRANDED SIRNAS; NOVO DNA METHYLATION; MICRORNA EXPRESSION; ENDOGENOUS SIRNAS; PIRNA PATHWAY; MESSENGER-RNA; BIOGENESIS PATHWAYS;

D O I：

10.3109/10409238.2013.844092

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The past two decades have seen an explosion in research on non-coding RNAs and their physiological and pathological functions. Several classes of small (20-30 nucleotides) and long (>200 nucleotides) non-coding RNAs have been firmly established as key regulators of gene expression in myriad processes ranging from embryonic development to innate immunity. In this review, we focus on our current understanding of the molecular mechanisms underlying the biogenesis and function of small interfering RNAs (siRNAs), microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs). In addition, we briefly review the relevance of small and long non-coding RNAs to human physiology and pathology and their potential to be exploited as therapeutic agents.

引用

页码：16 / 32

页数：17

共 233 条

[1]

Allen E, 2005, CELL, V121, P207, DOI 10.1016/j.cell.2005.04.004

[2] The functions of animal microRNAs [J].

Ambros, V .

NATURE, 2004, 431 (7006) :350-355

[3] MicroRNAs and developmental timing [J].

Ambros, Victor .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2011, 21 (04) :511-517

[4] The tudor domain protein Kumo is required to assemble the nuage and to generate germline piRNAs in Drosophila [J].

Anand, Amit ;

Kai, Toshie .

EMBO JOURNAL, 2012, 31 (04) :870-882

[5] The small RNA profile during Drosophila melanogaster development [J].

Aravin, AA ;

Lagos-Quintana, M ;

Yalcin, A ;

Zavolan, M ;

Marks, D ;

Snyder, B ;

Gaasterland, T ;

Meyer, J ;

Tuschl, T .

DEVELOPMENTAL CELL, 2003, 5 (02) :337-350

[6] A novel class of small RNAs bind to MILI protein in mouse testes [J].

Aravin, Alexei ;

Gaidatzis, Dimos ;

Pfeffer, Sebastien ;

Lagos-Quintana, Mariana ;

Landgraf, Pablo ;

Iovino, Nicola ;

Morris, Patricia ;

Brownstein, Michael J. ;

Kuramochi-Miyagawa, Satomi ;

Nakano, Toru ;

Chien, Minchen ;

Russo, James J. ;

Ju, Jingyue ;

Sheridan, Robert ;

Sander, Chris ;

Zavolan, Mihaela ;

Tuschl, Thomas .

NATURE, 2006, 442 (7099) :203-207

[7] A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice [J].

Aravin, Alexei A. ;

Sachidanandam, Ravi ;

Bourc'his, Deborah ;

Schaefer, Christopher ;

Pezic, Dubravka ;

Toth, Katalin Fejes ;

Bestor, Timothy ;

Hannon, Gregory J. .

MOLECULAR CELL, 2008, 31 (06) :785-799

[8] Small RNA guides for de novo DNA methylation in mammalian germ cells [J].

Aravin, Alexei A. ;

Bourc'his, Deborah .

GENES & DEVELOPMENT, 2008, 22 (08) :970-975

[9] Developmentally regulated piRNA clusters implicate MILI in transposon control [J].

Aravin, Alexei A. ;

Sachidanandam, Ravi ;

Girard, Angelique ;

Fejes-Toth, Katalin ;

Hannon, Gregory J. .

SCIENCE, 2007, 316 (5825) :744-747

[10] Classification and Comparison of Small RNAs from Plants [J].

Axtell, Michael J. .

ANNUAL REVIEW OF PLANT BIOLOGY, VOL 64, 2013, 64 :137-159

← 1 2 3 4 5 6 7 8 9 10 →