Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis

被引：602

作者：

Belisle, JT ^{[1
]}

Vissa, VD ^{[1
]}

Sievert, T ^{[1
]}

Takayama, K ^{[1
]}

Brennan, PJ ^{[1
]}

Besra, GS ^{[1
]}

机构：

[1] UNIV WISCONSIN, WILLIAM S MIDDLETON MEM VET HOSP, MYCOBACTERIOL RES LAB, MADISON, WI 53705 USA

来源：

SCIENCE | 1997年 / 276卷 / 5317期

关键词：

D O I：

10.1126/science.276.5317.1420

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The dominant exported proteins and protective antigens of Mycobacterium tuberculosis are a triad of related gene products called the antigen 85 (Ag85) complex. Each has also been implicated in disease pathogenesis through its fibronectin-binding capacities, A carboxylesterase domain was found within the amino acid sequences of Ag85A, B, and C, and each protein acted as a mycolyltransferase involved in the final stages of mycobacterial cell wall assembly, as shown by direct enzyme assay and site-directed mutagenesis. Furthermore, the use of an antagonist (6-azido-6-deoxy-alpha,alpha'-trehalose) of this activity demonstrates that these proteins are essential and potential targets for new antimycobacterial drugs.

引用

页码：1420 / 1422

页数：3

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