Synthesis of Original 2-Substituted 4-Arylquinazolines by Microwave-Irradiated Suzuki-Miyaura Cross-Coupling Reactions

被引：25

作者：

Kabri, Youssef ^{[1
,2
,3
]}

Gellis, Armand ^{[1
,2
,3
]}

Vanelle, Patrice ^{[1
,2
,3
]}

机构：

[1] Univ Aix Marseille 1, Lab Chim Provence, Fac Pharm, LPCR, F-13385 Marseille 05, France

[2] Univ Aix Marseille 2, F-13385 Marseille 05, France

[3] Univ Aix Marseille 3, CNRS, UMR 6264, Lab Chim Provence, F-13385 Marseille 05, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 2009卷 / 24期

关键词：

Boron; Microwave chemistry; Cross-coupling; Nitrogen heterocycles; DIHYDROFOLATE-REDUCTASE; ASSISTED SYNTHESIS; AQUEOUS-PHASE; ARYL BROMIDES; CATALYST-FREE; SOLVENT; DERIVATIVES; RESOLUTION; WATER;

D O I：

10.1002/ejoc.200900421

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Original 2-substituted 4-arylquinazolines have been synthesized by using a microwave-assisted Suzuki-Miyaura cross-coupling approach. The optimization and generalization of the Suzuki-Miyaura cross-coupling reaction between 2-substituted 4-chloroquinazolines and various boronic acids are described herein. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

引用

页码：4059 / 4066

页数：8

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