Synthesis of Original 2-Substituted 4-Arylquinazolines by Microwave-Irradiated Suzuki-Miyaura Cross-Coupling Reactions

被引：25
|
作者：
Kabri, Youssef [1 ,2 ,3 ]
Gellis, Armand [1 ,2 ,3 ]
Vanelle, Patrice [1 ,2 ,3 ]
机构：
[1] Univ Aix Marseille 1, Lab Chim Provence, Fac Pharm, LPCR, F-13385 Marseille 05, France
[2] Univ Aix Marseille 2, F-13385 Marseille 05, France
[3] Univ Aix Marseille 3, CNRS, UMR 6264, Lab Chim Provence, F-13385 Marseille 05, France
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 2009卷 / 24期
关键词：
Boron; Microwave chemistry; Cross-coupling; Nitrogen heterocycles; DIHYDROFOLATE-REDUCTASE; ASSISTED SYNTHESIS; AQUEOUS-PHASE; ARYL BROMIDES; CATALYST-FREE; SOLVENT; DERIVATIVES; RESOLUTION; WATER;
D O I：
10.1002/ejoc.200900421
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Original 2-substituted 4-arylquinazolines have been synthesized by using a microwave-assisted Suzuki-Miyaura cross-coupling approach. The optimization and generalization of the Suzuki-Miyaura cross-coupling reaction between 2-substituted 4-chloroquinazolines and various boronic acids are described herein. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
引用
收藏
页码：4059 / 4066
页数：8
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