Systemic inflammation, as measured by the neutrophil/lymphocyte ratio, may have differential prognostic impact before and during treatment with fluorouracil, irinotecan and bevacizumab in metastatic colorectal cancer patients
被引:51
作者:
Formica, Vincenzo
论文数: 0引用数: 0
h-index: 0
机构:
Tor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, ItalyTor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, Italy
Formica, Vincenzo
[1
]
Luccchetti, Jessica
论文数: 0引用数: 0
h-index: 0
机构:
Tor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, ItalyTor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, Italy
Luccchetti, Jessica
[1
]
Cunningham, David
论文数: 0引用数: 0
h-index: 0
机构:
Royal Marsden Hosp, Gastrointestinal Res Units, Dept Med, Sutton, Surrey, EnglandTor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, Italy
Cunningham, David
[2
]
Smyth, Elizabeth C.
论文数: 0引用数: 0
h-index: 0
机构:
Royal Marsden Hosp, Gastrointestinal Res Units, Dept Med, Sutton, Surrey, EnglandTor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, Italy
Smyth, Elizabeth C.
[2
]
Ferroni, Patrizia
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS San Raffaele Pisana, Dept Adv Biotechnol & Bioimaging, Rome, ItalyTor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, Italy
Ferroni, Patrizia
[3
]
Nardecchia, Antonella
论文数: 0引用数: 0
h-index: 0
机构:
Tor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, ItalyTor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, Italy
Nardecchia, Antonella
[1
]
Tesauro, Manfredi
论文数: 0引用数: 0
h-index: 0
机构:
Tor Vergata Univ Hosp Rome, Dept Internal Med, Rome, ItalyTor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, Italy
Tesauro, Manfredi
[4
]
Cereda, Vittore
论文数: 0引用数: 0
h-index: 0
机构:
Tor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, ItalyTor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, Italy
Cereda, Vittore
[1
]
Guadagni, Fiorella
论文数: 0引用数: 0
h-index: 0
机构:
IRCCS San Raffaele Pisana, Dept Adv Biotechnol & Bioimaging, Rome, ItalyTor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, Italy
Guadagni, Fiorella
[3
]
Roselli, Mario
论文数: 0引用数: 0
h-index: 0
机构:
Tor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, ItalyTor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, Italy
Roselli, Mario
[1
]
机构:
[1] Tor Vergata Univ Hosp, Med Oncol Unit, Dept Internal Med, I-00133 Rome, Italy
[2] Royal Marsden Hosp, Gastrointestinal Res Units, Dept Med, Sutton, Surrey, England
The inflammatory index neutrophil/lymphocyte ratio (NLR) has an adverse prognostic value in patients with localized colorectal cancer (CRC). We aimed at evaluating its role in metastatic CRC (mCRC) patients treated with standard first-line chemotherapy. Among consecutive CRC patients referred to our Unit, those with metastatic disease eligible for treatment with fluorouracil, irinotecan and bevacizumab (FOLFIRI-Bev) were included in the study. NLR was routinely assessed before each treatment cycle and correlated with outcome together with common clinical, biochemical and histological variables. A sub-analysis focused on patients with stable disease (SD) was also performed to test the net influence of NLR changes independently of tumor shrinkage. At multivariate Cox regression analysis, baseline NLR, taken as continuous variable, was the most powerful prognosticator for survival (HR 1.80, p 0.0019). Surprisingly, among SD patients, the prognostic effect of NLR changes after two cycles of therapy was of opposite sign, and those in whom NLR increased or was maintained had a 67 % reduction in the risk of death as compared with patients with significant NLR decrease: mOS 56 versus 23 months, respectively, p 0.02. In conclusion, we were able to confirm the adverse prognostic value of high baseline NLR for mCRC patients treated with FOLFIRI-Bev. However, FOLFIRI-Bev-induced NLR changes in SD patients seem to differently affect survival. The specific molecular pathways involved in NLR modulation by FOLFIRI-Bev warrant further investigation.
机构:
Univ Washington, Seattle, WA 98195 USA
Seattle Canc Care Alliance, Fred Hutchinson Canc Res Ctr, Seattle, WA USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Tykodi, Scott S.
;
Chow, Laura Q. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Seattle, WA 98195 USA
Seattle Canc Care Alliance, Fred Hutchinson Canc Res Ctr, Seattle, WA USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Chow, Laura Q. M.
;
Hwu, Wen-Jen
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
机构:
St Lukes Episcopal Hosp, Ctr Canc, Houston, TX 77030 USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Camacho, Luis H.
;
Kauh, John
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Kauh, John
;
Odunsi, Kunle
论文数: 0引用数: 0
h-index: 0
机构:
Roswell Pk Canc Inst, Buffalo, NY 14263 USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Odunsi, Kunle
;
Pitot, Henry C.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Coll Med, Rochester, MN USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Pitot, Henry C.
;
Hamid, Omid
论文数: 0引用数: 0
h-index: 0
机构:
Angeles Clin, Santa Monica, CA USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Hamid, Omid
;
论文数: 引用数:
h-index:
机构:
Bhatia, Shailender
;
Martins, Renato
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Seattle, WA 98195 USA
Seattle Canc Care Alliance, Fred Hutchinson Canc Res Ctr, Seattle, WA USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Martins, Renato
;
Eaton, Keith
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Seattle, WA 98195 USA
Seattle Canc Care Alliance, Fred Hutchinson Canc Res Ctr, Seattle, WA USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
机构:
Concord Repatriat Gen Hosp, Sydney Canc Ctr, Concord, NSW 2139, Australia
Univ Sydney, Fac Med, Sydney, NSW 2006, AustraliaConcord Repatriat Gen Hosp, Sydney Canc Ctr, Concord, NSW 2139, Australia
Chua, W.
;
Charles, K. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sydney, Bosch Inst, Sydney, NSW 2006, Australia
Univ Sydney, Sch Med Sci Pharmacol, Sydney, NSW 2006, AustraliaConcord Repatriat Gen Hosp, Sydney Canc Ctr, Concord, NSW 2139, Australia
Charles, K. A.
;
Baracos, V. E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alberta, Dept Oncol, Edmonton, AB, CanadaConcord Repatriat Gen Hosp, Sydney Canc Ctr, Concord, NSW 2139, Australia
Baracos, V. E.
;
Clarke, S. J.
论文数: 0引用数: 0
h-index: 0
机构:
Concord Repatriat Gen Hosp, Sydney Canc Ctr, Concord, NSW 2139, Australia
Univ Sydney, Fac Med, Sydney, NSW 2006, AustraliaConcord Repatriat Gen Hosp, Sydney Canc Ctr, Concord, NSW 2139, Australia
机构:
Univ Washington, Seattle, WA 98195 USA
Seattle Canc Care Alliance, Fred Hutchinson Canc Res Ctr, Seattle, WA USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Tykodi, Scott S.
;
Chow, Laura Q. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Seattle, WA 98195 USA
Seattle Canc Care Alliance, Fred Hutchinson Canc Res Ctr, Seattle, WA USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Chow, Laura Q. M.
;
Hwu, Wen-Jen
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
机构:
St Lukes Episcopal Hosp, Ctr Canc, Houston, TX 77030 USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Camacho, Luis H.
;
Kauh, John
论文数: 0引用数: 0
h-index: 0
机构:
Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Kauh, John
;
Odunsi, Kunle
论文数: 0引用数: 0
h-index: 0
机构:
Roswell Pk Canc Inst, Buffalo, NY 14263 USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Odunsi, Kunle
;
Pitot, Henry C.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Coll Med, Rochester, MN USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Pitot, Henry C.
;
Hamid, Omid
论文数: 0引用数: 0
h-index: 0
机构:
Angeles Clin, Santa Monica, CA USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Hamid, Omid
;
论文数: 引用数:
h-index:
机构:
Bhatia, Shailender
;
Martins, Renato
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Seattle, WA 98195 USA
Seattle Canc Care Alliance, Fred Hutchinson Canc Res Ctr, Seattle, WA USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
Martins, Renato
;
Eaton, Keith
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Seattle, WA 98195 USA
Seattle Canc Care Alliance, Fred Hutchinson Canc Res Ctr, Seattle, WA USASidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
机构:
Concord Repatriat Gen Hosp, Sydney Canc Ctr, Concord, NSW 2139, Australia
Univ Sydney, Fac Med, Sydney, NSW 2006, AustraliaConcord Repatriat Gen Hosp, Sydney Canc Ctr, Concord, NSW 2139, Australia
Chua, W.
;
Charles, K. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sydney, Bosch Inst, Sydney, NSW 2006, Australia
Univ Sydney, Sch Med Sci Pharmacol, Sydney, NSW 2006, AustraliaConcord Repatriat Gen Hosp, Sydney Canc Ctr, Concord, NSW 2139, Australia
Charles, K. A.
;
Baracos, V. E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alberta, Dept Oncol, Edmonton, AB, CanadaConcord Repatriat Gen Hosp, Sydney Canc Ctr, Concord, NSW 2139, Australia
Baracos, V. E.
;
Clarke, S. J.
论文数: 0引用数: 0
h-index: 0
机构:
Concord Repatriat Gen Hosp, Sydney Canc Ctr, Concord, NSW 2139, Australia
Univ Sydney, Fac Med, Sydney, NSW 2006, AustraliaConcord Repatriat Gen Hosp, Sydney Canc Ctr, Concord, NSW 2139, Australia