Synthesis of new fluorinated 1,5-benzoxazepine derivatives

被引：13

作者：

Cocco, MT ^{[1
]}

Congiu, C ^{[1
]}

Onnis, V ^{[1
]}

Bernard, AM ^{[1
]}

Piras, PP ^{[1
]}

机构：

[1] UNIV CAGLIARI,DIPARTIMENTO SCI CHIM,I-09124 CAGLIARI,ITALY

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 04期

关键词：

D O I：

10.1002/jhet.5570340442

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple approach to the fluorinated 1,5-benzoxazepine ring system is described. By reacting commercially accessible aminophenols 1 and the trifluoroacetylvinyl ether 2, high yields of enaminones 3 were obtained. Functionalization of methyl group of compounds 3 gave rise to dieneamines 4 that were cyclized in acidic environment to benzoxazepine derivatives 5.

引用

页码：1347 / 1350

页数：4