Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study

被引：13

作者：

Fantony, Joseph J. ^{[1
]}

Howard, Lauren E. ^{[2
,3
]}

Csizmadi, Ilona ^{[4
]}

Armstrong, Andrew J. ^{[5
]}

Lark, Amy L. ^{[6
,7
]}

Galet, Colette ^{[8
,9
]}

Aronson, William J. ^{[8
,10
]}

Freedland, Stephen J. ^{[2
,4
]}

机构：

[1] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

[2] Durham Vet Affairs Med Ctr, Urol Sect, Durham, NC 27705 USA

[3] Duke Sch Med, Dept Biostat & Bioinformat, Durham, NC 27705 USA

[4] Cedars Sinai Med Ctr, Dept Surg, Los Angeles, CA 90048 USA

[5] Duke Univ, Sch Med, Dept Med, Durham, NC 27710 USA

[6] Duke Univ Hosp, Dept Pathol, Durham, NC 27710 USA

[7] Durham Vet Affairs Med Ctr, Dept Pathol, Durham, NC 27710 USA

[8] Univ Calif Los Angeles, David Geffen Sch Med, Dept Urol, Los Angeles, CA 90095 USA

[9] Univ Iowa, Dept Surg, Carver Coll Med, Div Acute Care Surg, Iowa City, IA 52242 USA

[10] Greater Los Angeles Vet Affairs Healthcare Syst, Dept Surg, Urol Sect, Los Angeles, CA 90073 USA

来源：

BIOMARKERS IN MEDICINE | 2018年 / 12卷 / 07期

关键词：

biochemical recurrence; castration-resistant prostate cancer; immunohistochemistry; Ki67; metastases; prostate cancer; tissue microarray; BREAST-CANCER; INTERNATIONAL KI67; LABELING INDEX; KI-67; METASTASIS;

D O I：

10.2217/bmm-2017-0322

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To test if Ki67 expression is prognostic for biochemical recurrence (BCR) after radical prostatectomy (RP). Methods: Ki67 immunohistochemistry was performed on tissue microarrays constructed from specimens obtained from 464 men undergoing RP at the Durham and West LA Veterans Affairs Hospitals. Hazard ratios (HR) for Ki67 expression and time to BCR were estimated using Cox regression. Results: Ki67 was associated with more recent surgery year (p < 0.001), positive margins (p = 0.001) and extracapsular extension (p < 0.001). In center-stratified analyses, the adjusted HR for Ki67 expression and BCR approached statistical significance for west LA (HR: 1.54; p = 0.06), but not Durham (HR: 1.10; p = 0.74). Conclusion: This multi-institutional ` real-world' study provides limited evidence for the prognostic role of Ki67 in predicting outcome after RP.

引用

页码：727 / 736

页数：10