Synthesis of Sugar-Boronic Acid Derivatives: A Class of Potential Agents for Boron Neutron Capture Therapy

被引：17

作者：

Imperio, Daniela ^{[1
]}

Del Grosso, Erika ^{[1
]}

Fallarini, Silvia ^{[1
]}

Lombardi, Grazia ^{[1
]}

Panza, Luigi ^{[1
]}

机构：

[1] Univ Piemonte Orientale, Dept Pharmaceut Sci, Largo Donegani 2, I-28100 Novara, Italy

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 07期

关键词：

CATALYZED BORYLATION; ALKYLBORONIC ESTERS; BETA-LACTAMASE; ALKYL-HALIDES; SECONDARY; INHIBITOR; CHEMISTRY; PALLADIUM; DISCOVERY; REAGENTS;

D O I：

10.1021/acs.orglett.7b00382

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

To date, sugar analogues that contain boronic acids as substithtes for hydroxyl groups are a class of compounds nearly unknown in the literature. The challenging synthesis of two sugar-boronic,acid analogues is described, and data are retrieved on their solution behavior,stability, and toxicity. As these compounds were expected to mimic the behavior of carbohydrates, they were tested in regards to their future development as potential boron neutron capture therapy agents.

引用

页码：1678 / 1681

页数：4

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