Death due to diabetic ketoacidosis: Induction by the consumption of synthetic cannabinoids?

被引：39

作者：

Hess, C. ^{[1
]}

Stockhausen, S. ^{[1
]}

Kernbach-Wighton, G. ^{[1
]}

Madea, B. ^{[1
]}

机构：

[1] Univ Bonn, Inst Forens Med, Dept Forens Toxicol, D-53111 Bonn, Germany

来源：

FORENSIC SCIENCE INTERNATIONAL | 2015年 / 257卷

关键词：

AB-FUBINACA; Synthetic cannabinoids; Diabetic coma; Ketoacidosis; POSTMORTEM DIAGNOSIS; CB2; RECEPTOR; INSULIN; IDENTIFICATION; GLUCOSE; UR-144; QUANTIFICATION; ANALOGS; SAMPLES; XLR-11;

D O I：

10.1016/j.forsciint.2015.08.012

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

We present a case study on a man who suffered from diabetic ketoacidosis, probably following consumption of synthetic cannabinoids. In blood from a femoral vein AB-CHMINACA, AB-FUBINACA, AM-2201, 5F-AMB, 5F-APINACA, EAM-2201, JWH-018, JWH-122, MAM-2201, STS135 and THJ 2201 could be detected by LC-MS/MS. Diagnosis of ketoacidosis as cause of death was carried out using biochemical measurements of glucose and lactate concentrations in vitreous humour (sum formula: 463 mg/dl) and cerebrospinal fluid (sum formula: 506 mg/dl), of acetone (163 mg/l in femoral venous blood) and of HbA1c (98 mmol/mol). Death due to hyperglycaemia could have been induced by skipping of insulin doses due to his intoxicated state or by the cannabinoids which were described to be able to produce hyperglycaemia themselves. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：E6 / E11

页数：6

共 42 条

[1] Four Postmortem Case Reports with Quantitative Detection of the Synthetic Cannabinoid, 5F-PB-22 [J].

Behonick, George ;

Shanks, Kevin G. ;

Firchau, Dennis J. ;

Mathur, Gagan ;

Lynch, Charles F. ;

Nashelsky, Marcus ;

Jaskierny, David J. ;

Meroueh, Chady .

JOURNAL OF ANALYTICAL TOXICOLOGY, 2014, 38 (08) :559-562

[2] Activation of cannabinoid CB1 receptors induces glucose intolerance in rats [J].

Bermúdez-Siva, FJ ;

Serrano, A ;

Diaz-Molina, FJ ;

Vera, IS ;

Juan-Pico, P ;

Nadal, A ;

Fuentes, E ;

de Fonseca, FR .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 531 (1-3) :282-284

[3]

Coe J I, 1977, Leg Med Annu, V1976, P55

[4] Atypical Diabetic Ketoacidosis: Case Report [J].

Demirci, Huseyin ;

Cosar, Ramazan ;

Ciftci, Ozcan ;

Sari, Isilay Kalan .

BALKAN MEDICAL JOURNAL, 2015, 32 (01) :124-126

[5]

Deng H., 2007, WO patent, Patent No. 200128557

[6] OBTAINING SAMPLES AT POSTMORTEM EXAMINATION FOR TOXICOLOGICAL AND BIOCHEMICAL ANALYSES [J].

FORREST, ARW .

JOURNAL OF CLINICAL PATHOLOGY, 1993, 46 (04) :292-296

[7] Urinary excretion profiles of 11-nor-9-carboxy-Δ9-tetrahydropannabinol:: a Δ9-THC-COOH to creatinine ratio study #2 [J].

Fraser, AD ;

Worth, D .

FORENSIC SCIENCE INTERNATIONAL, 2003, 133 (1-2) :26-31

[8] THE DIAGNOSTIC-VALUE OF POSTMORTEM BLOOD-GLUCOSE DETERMINATIONS IN CASES OF DIABETES-MELLITUS [J].

GORMSEN, H ;

LUND, A .

FORENSIC SCIENCE INTERNATIONAL, 1985, 28 (02) :103-107

[9] 'Crazy Monkey' Poisons Man and Dog: Human and canine seizures due to PB-22, a novel synthetic cannabinoid [J].

Gugelmann, H. ;

Gerona, R. ;

Li, C. ;

Tsutaoka, B. ;

Olson, K. R. ;

Lung, D. .

CLINICAL TOXICOLOGY, 2014, 52 (06) :635-638

[10] Determination of hypoglycaemia induced by insulin or its synthetic analogues post mortem [J].

Hess, C. ;

Madea, B. ;

Daldrup, T. ;

Musshoff, F. .

DRUG TESTING AND ANALYSIS, 2013, 5 (9-10) :802-807

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