The influence of sodium on pathophysiology of multiple sclerosis

被引：20

作者：

Zostawa, Jacek ^{[1
]}

Adamczyk, Jowita ^{[1
]}

Sowa, Pawel ^{[2
]}

Adamczyk-Sowa, Monika ^{[1
]}

机构：

[1] Med Univ Silesia, Dept Neurol Zabrze, Ul 3 Go Maja 13-15, PL-41800 Zabrze, Poland

[2] Med Univ Silesia, Dept Otorhinolaryngol & Oncol Laryngol, Ul C Sklodowskiej 10, PL-41800 Zabrze, Poland

来源：

NEUROLOGICAL SCIENCES | 2017年 / 38卷 / 03期

关键词：

Sodium chloride intake; Multiple sclerosis; Environmental factors in MS; VGSCs; EPSTEIN-BARR-VIRUS; GATED NA+ CHANNELS; VITAMIN-A SUPPLEMENTATION; PATHOGENIC T(H)17 CELLS; DOUBLE-BLIND; DISEASE PROGRESSION; TETRODOTOXIN-RESISTANT; MECHANICAL ALLODYNIA; FEBRILE SEIZURES; IMMUNE-RESPONSE;

D O I：

10.1007/s10072-016-2802-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune disease of the central nervous system, and is an important cause of disability in young adults. In genetically susceptible individuals, several environmental factors may play a partial role in the pathogenesis of MS. Some studies suggests that high-salt diet (> 5 g/day) may contribute to the MS and other autoimmune disease development through the induction of pathogenic Th17 cells and pro-inflammatory cytokines in both humans and mice. However, the precise mechanisms of pro-inflammatory effect of sodium chloride intake are not yet explained. The purpose of this review was to discuss the present state of knowledge on the potential role of environmental and dietary factors, particularly sodium chloride on the development and course of MS.

引用

页码：389 / 398

页数：10

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