Mitochondrial metabolism and the control of vascular smooth muscle cell proliferation

被引:103
作者
Chiong, Mario [1 ]
Cartes-Saavedra, Benjamin [1 ]
Norambuena-Soto, Ignacio [1 ]
Mondaca-Ruff, David [1 ]
Morales, Pablo E. [1 ]
Garcia-Miguel, Marina [1 ]
Mellado, Rosemarie [2 ]
机构
[1] Univ Chile, Adv Ctr Chron Dis, Fac Chem & Pharmaceut Sci, Livingstone P 1007, Santiago 8380492, Chile
[2] Pontificia Univ Catolica Chile, Fac Chem, Santiago, Chile
关键词
vascular smooth muscle cell; proliferation; mitofusin-2; mitochondrial metabolism; mitochondrial dynamics;
D O I
10.3389/fcell.2014.00072
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Differentiation and dedifferentiation of vascular smooth muscle cells (VSMCs) are essential processes of vascular development. VSMC have biosynthetic, proliferative, and contractile roles in the vessel wall. Alterations in the differentiated state of the VSMC play a critical role in the pathogenesis of a variety of cardiovascular diseases, including atherosclerosis, hypertension, and vascular stenosis. This review provides an overview of the current state of knowledge of molecular mechanisms involved in the control of VSMC proliferation, with particular focus on mitochondrial metabolism. Mitochondrial activity can be controlled by regulating mitochondrial dynamics, i.e., mitochondrial fusion and fission, and by regulating mitochondrial calcium handling through the interaction with the endoplasmic reticulum (ER). Alterations in both VSMC proliferation and mitochondrial function can be triggered by dysregulation of mitofusin-2, a small GTPase associated with mitochondrial fusion and mitochondrial-ER interaction. Several lines of evidence highlight the relevance of mitochondrial metabolism in the control of VSMC proliferation, indicating a new area to be explored in the treatment of vascular diseases.
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页数:9
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