Gene expression profile in the peripheral blood of patients with prostate cancer and benign prostatic hyperplasia

被引：11

作者：

Alonso, Vivian ^{[1
]}

Neves, Adriana F. ^{[1
]}

Marangoni, Karina ^{[1
]}

Faria, Paula C. B. ^{[1
]}

Freschi, Ana Paula P. ^{[1
]}

Capaneli, Andreia C. ^{[1
]}

Meola, Juliana ^{[1
]}

Goulart, Luiz R. ^{[1
]}

机构：

[1] Univ Fed Uberlandia, Inst Genet & Biochem, Lab Nanobiotechnol, BR-38400902 Uberlandia, MG, Brazil

来源：

CANCER DETECTION AND PREVENTION | 2009年 / 32卷 / 04期

关键词：

Gene expression; Slot-blot array; Prostate cancer; Peripheral blood;

D O I：

10.1016/j.cdp.2008.10.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Prostate cancer consists of multifactorial and multifocal events, generating differential gene expression in tumor cells. Methods: The molecular profile of 14 gene expression was analyzed through cDNA array in blood samples of patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH). Results: Messenger RNA from patient's blood showed significant differences between PCa and BPH groups only for the NOS3 gene, with an occurrence chance for PCa 5.8-fold higher than BPH disease. Conclusion: The NOS3 gene expression in the patient's blood may be used as a putative biomarker for prostate cancer. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：336 / 337

页数：2