Effects of Uremic Toxins from the Gut Microbiota on Bone: A Brief Look at Chronic Kidney Disease

被引：18

作者：

Black, Ana Paula ^{[1
]}

Cardozo, Ludmila F. M. F. ^{[2
]}

Mafra, Denise ^{[1
,2
]}

机构：

[1] Univ Fed Fluminense, Grad Program Med Sci, Niteroi, RJ, Brazil

[2] Univ Fed Fluminense, Grad Program Cardiovasc Sci, Niteroi, RJ, Brazil

来源：

THERAPEUTIC APHERESIS AND DIALYSIS | 2015年 / 19卷 / 05期

关键词：

Bone mineral disease; Chronic kidney disease; Uremic toxins; P-CRESYL SULFATE; INDOXYL SULFATE; OXIDATIVE STRESS; SKELETAL RESISTANCE; CLASSIFICATION; ASSOCIATION; PROGRESSION; MORTALITY;

D O I：

10.1111/1744-9987.12307

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with chronic kidney disease (CKD) frequently have mineral and bone disorders (CKD-MBD) that are caused by several mechanisms. Recent research has suggested that uremic toxins from the gut such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS) could also be involved in the development of bone disease in patients with CKD. IS and PCS are produced by microbiota in the gut, carried into the plasma bound to serum albumin, and are normally excreted into the urine. However, in patients with CKD, there is an accumulation of high levels of these uremic toxins. The exact mechanisms of action of uremic toxins in bone disease remain unclear. The purpose of this brief review is to discuss the link between uremic toxins (IS and PCS) and bone mineral disease in chronic kidney disease.

引用

页码：436 / 440

页数：5

共 38 条

[11] Accumulated uremic toxins attenuate bone mechanical properties in rats with chronic kidney disease [J].

Iwasaki, Yoshiko ;

Kazama, Junichiro James ;

Yamato, Hideyuki ;

Shimoda, Hiroshi ;

Fukagawa, Masafumi .

BONE, 2013, 57 (02) :477-483

[12] Changes in chemical composition of cortical bone associated with bone fragility in rat model with chronic kidney disease [J].

Iwasaki, Yoshiko ;

Kazama, Junichiro James ;

Yamato, Hideyuki ;

Fukagawa, Masafumi .

BONE, 2011, 48 (06) :1260-1267

[13] Low bone mineral density and fractures in long-term hemodialysis patients: A meta-analysis [J].

Jamal, Sophie A. ;

Hayden, Jill A. ;

Beyene, Joseph .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2007, 49 (05) :674-681

[14] Uremic osteoporosis [J].

Kazama, Junichiro J. ;

Iwasaki, Yoshiko ;

Fukagawa, Masafumi .

KIDNEY INTERNATIONAL SUPPLEMENTS, 2013, 3 (05) :446-450

[15]

Kim Y, 2013, BMC PHARMACOL TOXICO, V14, P1

[16] Protein-Bound Uremic Toxins: New Insight from Clinical Studies [J].

Liabeuf, Sophie ;

Drueeke, Tilman B. ;

Massy, Ziad A. .

TOXINS, 2011, 3 (07) :911-919

[17] Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney disease [J].

Liabeuf, Sophie ;

Barreto, Daniela V. ;

Barreto, Fellype C. ;

Meert, Natalie ;

Glorieux, Grief ;

Schepers, Eva ;

Temmar, Mohammed ;

Choukroun, Gabriel ;

Vanholder, Raymond ;

Massy, Ziad A. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2010, 25 (04) :1183-1191

[18] Association of Indoxyl Sulfate With Fibroblast Growth Factor 23 in Patients With Advanced Chronic Kidney Disease [J].

Lin, Cheng-Jui ;

Pan, Chi-Feng ;

Chuang, Chih-Kuang ;

Liu, Hsuan-Liang ;

Sun, Fang-Ju ;

Wang, Tuen-Jen ;

Chen, Han-Hsiang ;

Wu, Chih-Jen .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2014, 347 (05) :370-376

[19] Uraemic toxins for consideration by the cardiologist-Beyond traditional and non-traditional cardiovascular risk factors [J].

Massy, Ziad A. ;

Barreto, Daniela V. ;

Barreto, Fellype C. ;

Vanholder, Raymond .

ATHEROSCLEROSIS, 2010, 211 (02) :381-383

[20] p-Cresyl Sulfate and Indoxyl Sulfate in Hemodialysis Patients [J].

Meijers, Bjoern. K. I. ;

De Loor, Henriette ;

Bammens, Bert ;

Verbeke, Kristin ;

Vanrenterghem, Yves ;

Evenepoel, Pieter .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 4 (12) :1932-1938

← 1 2 3 4 →