Effects of Uremic Toxins from the Gut Microbiota on Bone: A Brief Look at Chronic Kidney Disease

被引：18

作者：

Black, Ana Paula ^{[1
]}

Cardozo, Ludmila F. M. F. ^{[2
]}

Mafra, Denise ^{[1
,2
]}

机构：

[1] Univ Fed Fluminense, Grad Program Med Sci, Niteroi, RJ, Brazil

[2] Univ Fed Fluminense, Grad Program Cardiovasc Sci, Niteroi, RJ, Brazil

来源：

THERAPEUTIC APHERESIS AND DIALYSIS | 2015年 / 19卷 / 05期

关键词：

Bone mineral disease; Chronic kidney disease; Uremic toxins; P-CRESYL SULFATE; INDOXYL SULFATE; OXIDATIVE STRESS; SKELETAL RESISTANCE; CLASSIFICATION; ASSOCIATION; PROGRESSION; MORTALITY;

D O I：

10.1111/1744-9987.12307

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with chronic kidney disease (CKD) frequently have mineral and bone disorders (CKD-MBD) that are caused by several mechanisms. Recent research has suggested that uremic toxins from the gut such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS) could also be involved in the development of bone disease in patients with CKD. IS and PCS are produced by microbiota in the gut, carried into the plasma bound to serum albumin, and are normally excreted into the urine. However, in patients with CKD, there is an accumulation of high levels of these uremic toxins. The exact mechanisms of action of uremic toxins in bone disease remain unclear. The purpose of this brief review is to discuss the link between uremic toxins (IS and PCS) and bone mineral disease in chronic kidney disease.

引用

页码：436 / 440

页数：5

共 38 条

[1] Mineral Metabolic Abnormalities and Mortality in Dialysis Patients [J].

Abe, Masanori ;

Okada, Kazuyoshi ;

Soma, Masayoshi .

NUTRIENTS, 2013, 5 (03) :1002-1023

[2] Does the Adequacy Parameter Kt/Vurea Reflect Uremic Toxin Concentrations in Hemodialysis Patients? [J].

Eloot, Sunny ;

Van Biesen, Wim ;

Glorieux, Griet ;

Neirynck, Nathalie ;

Dhondt, Annemieke ;

Vanholder, Raymond .

PLOS ONE, 2013, 8 (11)

[3] Uremic toxins originating from colonic microbial metabolism [J].

Evenepoel, Pieter ;

Meijers, Bjorn K. I. ;

Bammens, Bert R. M. ;

Verbeke, Kristin .

KIDNEY INTERNATIONAL, 2009, 76 :S12-S19

[4] Role of Oxidative Stress and Indoxyl Sulfate in Progression of Cardiovascular Disease in Chronic Kidney Disease [J].

Fujii, Hideki ;

Nakai, Kentaro ;

Fukagawa, Masafumi .

THERAPEUTIC APHERESIS AND DIALYSIS, 2011, 15 (02) :125-128

[5] Uremic Toxins and Oral Adsorbents [J].

Goto, Shunsuke ;

Yoshiya, Kunihiko ;

Kita, Tomoyuki ;

Fujii, Hideki ;

Fukagawa, Masafumi .

THERAPEUTIC APHERESIS AND DIALYSIS, 2011, 15 (02) :132-134

[6] Association Between Indoxyl Sulfate and Skeletal Resistance in Hemodialysis Patients [J].

Goto, Shunsuke ;

Fujii, Hideki ;

Hamada, Yasuhiro ;

Yoshiya, Kunihiko ;

Fukagawa, Masafumi .

THERAPEUTIC APHERESIS AND DIALYSIS, 2010, 14 (04) :417-423

[7] High Correlation Between Clearance of Renal Protein-Bound Uremic Toxins (Indoxyl Sulfate and p-Cresyl Sulfate) and Renal Water-Soluble Toxins in Peritoneal Dialysis Patients [J].

Huang, Wen-Hung ;

Hung, Cheng-Chieh ;

Yang, Chih-Wei ;

Huang, Jeng-Yi .

THERAPEUTIC APHERESIS AND DIALYSIS, 2012, 16 (04) :361-367

[8] Uremic toxins impair human bone marrow-derived mesenchymal stem cells functionality in vitro [J].

Idziak, Marta ;

Pedzisz, Piotr ;

Burdzinska, Anna ;

Gala, Kamila ;

Paczek, Leszek .

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2014, 66 (04) :187-194

[9] Uremic toxin and bone metabolism [J].

Iwasaki, Y ;

Yamato, H ;

Nii-Kono, T ;

Fujieda, A ;

Uchida, M ;

Hosokawa, A ;

Motojima, M ;

Fukagawa, M .

JOURNAL OF BONE AND MINERAL METABOLISM, 2006, 24 (02) :172-175

[10] Administration of oral charcoal adsorbent (AST-120) suppresses low-turnover bone progression in uraemic rats [J].

Iwasaki, Yoshiko ;

Yamato, Hideyuki ;

Nii-Kono, Tomoko ;

Fujieda, Ayako ;

Uchida, Motoyuki ;

Hosokawa, Atsuko ;

Motojima, Masaru ;

Fukagawa, Masafumi .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (10) :2768-2774

← 1 2 3 4 →