The Influence of Sex on Patients with Rheumatoid Arthritis in a Large Observational Cohort

被引：55

作者：

Iikuni, Noriko ^{[1
,2
]}

Sato, Eri ^{[2
]}

Hoshi, Masaya

Inoue, Eisuke ^{[2
]}

Taniguchi, Atsuo ^{[2
]}

Hara, Masako ^{[2
]}

Tomatsu, Taisuke ^{[2
]}

Kamatani, Naoyuki ^{[2
]}

Yamanaka, Hisashi ^{[2
]}

机构：

[1] Univ Calif Los Angeles, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USA

[2] Tokyo Womens Med Univ, Inst Rheumatol, Los Angeles, CA USA

来源：

JOURNAL OF RHEUMATOLOGY | 2009年 / 36卷 / 03期

关键词：

RHEUMATOID ARTHRITIS; EPIDEMIOLOGY; SEX; PHENOTYPE; SEVERITY;

D O I：

10.3899/jrheum.080724

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To compare the sex differences of various components of rheumatoid arthritis (RA). Methods. Data of 4823 patients from a large observational cohort study were analyzed. Remarkable C differences were noted between the sexes, and overall, women had significantly higher disease activity. Results. When variables were adjusted using sex, age, and duration, Health Assessment Questionnaire, rather than Disease Activity Score, contributed most to sex difference. Further analysis showed evidence that progression of disability was approximately 3 times more rapid in female patients compared to male patients. Conclusion. Women overall have hi-her RA disease activity and are prone to greater and faster progression of disability over time. (First Release Feb 1 2009; J Rheumatol 2009;36:508-11; doi:10.3899/jrheum.080724)

引用

页码：508 / 511

页数：4

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