Posttraumatic Stress Disorder After High-Dose-Rate Brachytherapy for Cervical Cancer With 2 Fractions in 1 Application Under Spinal/Epidural Anesthesia: Incidence and Risk Factors

被引：78

作者：

Kirchheiner, Kathrin ^{[1
,3
]}

Czajka-Pepl, Agnieszka ^{[1
]}

Ponocny-Seliger, Elisabeth ^{[4
]}

Scharbert, Gisela ^{[2
]}

Wetzel, Leonore ^{[2
]}

Nout, Remi A. ^{[5
]}

Sturdza, Alina ^{[1
]}

Dimopoulos, Johannes C. ^{[6
]}

Doerr, Wolfgang ^{[1
,3
]}

Poetter, Richard ^{[1
,3
]}

机构：

[1] Med Univ Vienna, Gen Hosp Vienna, Ctr Comprehens Canc, Dept Radiat Oncol, A-1090 Vienna, Austria

[2] Med Univ Vienna, Gen Hosp Vienna, Dept Anaesthesia Gen Intens Care & Pain Managemen, A-1090 Vienna, Austria

[3] Med Univ Vienna, Christian Doppler Lab Med Radiat Res Radiat Oncol, A-1090 Vienna, Austria

[4] Sigmund Freud Private Univ Vienna, Dept Psychol, Vienna, Austria

[5] Leiden Univ, Med Ctr, Dept Clin Oncol, Leiden, Netherlands

[6] Metropolitan Hosp, Athens, Greece

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2014年 / 89卷 / 02期

关键词：

QUALITY-OF-LIFE; LONG-TERM SURVIVORS; EUROPEAN-ORGANIZATION; HOSPITAL ANXIETY; RADIOTHERAPY; EXPERIENCE; CARCINOMA; ONCOLOGY; IMPACT; WOMEN;

D O I：

10.1016/j.ijrobp.2014.02.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: To investigate the psychological consequences of high- dose- rate brachytherapy with 2 fractions in 1 application under spinal/epidural anesthesia in the treatment of locally advanced cervical cancer. Methods and Materials: In 50 patients with locally advanced cervical cancer, validated questionnaires were used for prospective assessment of acute and posttraumatic stress disorder (ASD/PTSD) (Impact of Event Scale-Revision), anxiety/depression (Hospital Anxiety and Depression Scale), quality of life (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30/Cervical Cancer 24), physical functioning (World Health Organization performance status), and pain (visual analogue scale), before and during treatment and 1 week and 3 months after treatment. Qualitative interviews were recorded in open format for content analysis. Results: Symptoms of ASD occurred in 30% of patients 1 week after treatment; and of PTSD in 41% 3 months after treatment in association with this specific brachytherapy procedure. Pretreatment predictive variables explain 82% of the variance of PTSD symptoms. Helpful experiences were the support of the treatment team, psychological support,

引用

页码：260 / 267

页数：8

共 33 条

[1] THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER QLQ-C30 - A QUALITY-OF-LIFE INSTRUMENT FOR USE IN INTERNATIONAL CLINICAL-TRIALS IN ONCOLOGY [J].

AARONSON, NK ;

AHMEDZAI, S ;

BERGMAN, B ;

BULLINGER, M ;

CULL, A ;

DUEZ, NJ ;

FILIBERTI, A ;

FLECHTNER, H ;

FLEISHMAN, SB ;

DEHAES, JCJM ;

KAASA, S ;

KLEE, M ;

OSOBA, D ;

RAZAVI, D ;

ROFE, PB ;

SCHRAUB, S ;

SNEEUW, K ;

SULLIVAN, M ;

TAKEDA, F .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (05) :365-376

[2] Anaesthesia for brachytherapy -: 51/2 yr of experience in 1622 procedures [J].

Benrath, J ;

Kozek-Langenecker, S ;

Hüpfl, M ;

Lierz, P ;

Gustorff, B .

BRITISH JOURNAL OF ANAESTHESIA, 2006, 96 (02) :195-200

[3] Post-traumatic stress disorder (PTSD) in cardiology and oncology - which diagnostic tools should be used? [J].

Einsle, Franziska ;

Kraft, Dagmar ;

Koellner, Volker .

JOURNAL OF PSYCHOSOMATIC RESEARCH, 2012, 72 (06) :434-438

[4] Patterns of brachytherapy practice for patients with carcinoma of the cervix (1996-1999): A patterns of care study [J].

Erickson, B ;

Eifel, P ;

Moughan, J ;

Rownd, J ;

Iarocci, T ;

Owen, J .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2005, 63 (04) :1083-1092

[5]

Fayers P, 2002, EUR J CANCER, V38, pS125

[6] Quality of life and sexual functioning in cervical cancer survivors [J].

Frumovitz, M ;

Sun, CC ;

Schover, LR ;

Munsell, MF ;

Jhingran, A ;

Wharton, JT ;

Eifel, P ;

Bevers, TB ;

Levenback, CF ;

Gershenson, DM ;

Bodurka, DC .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (30) :7428-7436

[7] The European Organization for Research and Treatment of Cancer (EORTC) quality-of-life questionnaire cervical cancer module - EORTC QLQ-CX24 [J].

Greimel, Elfriede R. ;

Vlasic, Karin Kuljanic ;

Waldenstrom, Ann-Charlotte ;

Duric, Vlatka M. ;

Jensen, Pernille T. ;

Singer, Susanne ;

Chie, Weichu ;

Nordin, Andy ;

Radisic, Vesna Bjelic ;

Wydra, Dariusz .

CANCER, 2006, 107 (08) :1812-1822

[8]

Herrmann-Lingen C, 1995, HADS D HOSP ANXIETY

[9] Long-term survival from gynecologic cancer: Psychosocial outcomes, supportive care needs and positive outcomes [J].

Hodgkinson, Katharine ;

Butow, Phyllis ;

Fuchs, Anne ;

Hunt, Glenn E. ;

Stenlake, Annie ;

Hobbs, Kim M. ;

Brand, Alison ;

Wain, Gerard .

GYNECOLOGIC ONCOLOGY, 2007, 104 (02) :381-389

[10] Rehabilitation after critical illness: A randomized, controlled trial [J].

Jones, C ;

Skirrow, P ;

Griffiths, RD ;

Humphris, GH ;

Ingleby, S ;

Eddleston, J ;

Waldmann, C ;

Gager, M .

CRITICAL CARE MEDICINE, 2003, 31 (10) :2456-2461

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