Oxysterol research: a brief review

被引：68

作者：

Griffiths, William J. ^{[1
]}

Wang, Yuqin ^{[1
]}

机构：

[1] Swansea Univ, Med Sch, ILS1 Bldg,Singleton Pk, Swansea SA2 8PP, W Glam, Wales

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2019年 / 47卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

CHOLESTEROL-BIOSYNTHESIS PATHWAY; BILE-ACID SYNTHESIS; HUNTINGTONS-DISEASE; ACOX2; DEFICIENCY; PLASMA; 24S-HYDROXYCHOLESTEROL; CEREBROSPINAL-FLUID; SURROGATE MARKERS; ALPHA-SYNUCLEIN; CELL-MIGRATION; BINDING SITES;

D O I：

10.1042/BST20180135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study, we discuss the recent developments in oxysterol research. Exciting results have been reported relating to the involvement of oxysterols in the fields of neurodegenerative disease, especially in Huntington's disease, Parkinson's disease and Alzheimer's disease; in signalling and development, in particular, in relation to Hedgehog signalling; and in cancer, with a special focus on (25R)26-hydroxycholesterol. Methods for the measurement of oxysterols, essential for understanding their mechanism of action in vivo, and valuable for diagnosing rare diseases of cholesterol biosynthesis and metabolism are briefly considered.

引用

页码：517 / 526

页数：10

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