Oxysterol research: a brief review

被引：68

作者：

Griffiths, William J. ^{[1
]}

Wang, Yuqin ^{[1
]}

机构：

[1] Swansea Univ, Med Sch, ILS1 Bldg,Singleton Pk, Swansea SA2 8PP, W Glam, Wales

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2019年 / 47卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

CHOLESTEROL-BIOSYNTHESIS PATHWAY; BILE-ACID SYNTHESIS; HUNTINGTONS-DISEASE; ACOX2; DEFICIENCY; PLASMA; 24S-HYDROXYCHOLESTEROL; CEREBROSPINAL-FLUID; SURROGATE MARKERS; ALPHA-SYNUCLEIN; CELL-MIGRATION; BINDING SITES;

D O I：

10.1042/BST20180135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study, we discuss the recent developments in oxysterol research. Exciting results have been reported relating to the involvement of oxysterols in the fields of neurodegenerative disease, especially in Huntington's disease, Parkinson's disease and Alzheimer's disease; in signalling and development, in particular, in relation to Hedgehog signalling; and in cancer, with a special focus on (25R)26-hydroxycholesterol. Methods for the measurement of oxysterols, essential for understanding their mechanism of action in vivo, and valuable for diagnosing rare diseases of cholesterol biosynthesis and metabolism are briefly considered.

引用

页码：517 / 526

页数：10

共 84 条

[1] Defective cholesterol metabolism in amyotrophic lateral sclerosis [J].

Abdel-Khalik, Jonas ;

Yutuc, Eylan ;

Crick, Peter J. ;

Gustafsson, Jan-Ake ;

Warner, Margaret ;

Roman, Gustavo ;

Talbot, Kevin ;

Gray, Elizabeth ;

Griffiths, William J. ;

Turner, Martin R. ;

Wang, Yuqin .

JOURNAL OF LIPID RESEARCH, 2017, 58 (01) :267-278

[2] The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells [J].

Baek, Amy E. ;

Yu, Yen-Rei A. ;

He, Sisi ;

Wardell, Suzanne E. ;

Chang, Ching-Yi ;

Kwon, Sanghoon ;

Pillai, Ruchita V. ;

McDowell, Hannah B. ;

Thompson, J. Will ;

Dubois, Laura G. ;

Sullivan, Patrick M. ;

Kemper, Jongsook K. ;

Gunn, Michael D. ;

McDonnell, Donald P. ;

Nelson, Erik R. .

NATURE COMMUNICATIONS, 2017, 8

[3] Huntington disease [J].

Bates, Gillian P. ;

Dorsey, Ray ;

Gusella, James F. ;

Hayden, Michael R. ;

Kay, Chris ;

Leavitt, Blair R. ;

Nance, Martha ;

Ross, Christopher A. ;

Scahill, Rachael I. ;

Wetzel, Ronald ;

Wild, Edward J. ;

Tabrizi, Sarah J. .

NATURE REVIEWS DISEASE PRIMERS, 2015, 1

[4] 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production [J].

Bauman, David R. ;

Bitmansour, Andrew D. ;

McDonald, Jeffrey G. ;

Thompson, Bonne M. ;

Liang, Guosheng ;

Russell, David W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (39) :16764-16769

[5] Oxysterols and Alzheimer's disease [J].

Bjorkhem, I. ;

Heverin, M. ;

Leoni, V. ;

Meaney, S. ;

Diczfalusy, U. .

ACTA NEUROLOGICA SCANDINAVICA, 2006, 114 :43-49

[6] Rediscovery of cerebrosterol [J].

Bjorkhem, Ingemar .

LIPIDS, 2007, 42 (01) :5-14

[7] 24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson's Disease and Corticobasal Syndrome [J].

Bjorkhem, Ingemar ;

Patra, Kalicharan ;

Boxer, Adam L. ;

Svenningsson, Per .

FRONTIERS IN NEUROLOGY, 2018, 9

[8] Oxysterols and neurodegenerative diseases [J].

Bjorkhem, Ingemar ;

Cedazo-Minguez, Angel ;

Leoni, Valerio ;

Meaney, Steve .

MOLECULAR ASPECTS OF MEDICINE, 2009, 30 (03) :171-179

[9] The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response [J].

Blanc, Mathieu ;

Hsieh, Wei Yuan ;

Robertson, Kevin A. ;

Kropp, Kai A. ;

Forster, Thorsten ;

Shui, Guanghou ;

Lacaze, Paul ;

Watterson, Steven ;

Griffiths, Samantha J. ;

Spann, Nathanael J. ;

Meljon, Anna ;

Talbot, Simon ;

Krishnan, Kathiresan ;

Covey, Douglas F. ;

Wenk, Markus R. ;

Craigon, Marie ;

Ruzsics, Zsolts ;

Haas, Juergen ;

Angulo, Ana ;

Griffiths, William J. ;

Glass, Christopher K. ;

Wang, Yuqin ;

Ghazal, Peter .

IMMUNITY, 2013, 38 (01) :106-118

[10] Update on newborn dried bloodspot testing for cerebrotendinous xanthomatosis: An available high-throughput liquid-chromatography tandem mass spectrometry method [J].

Bleyle, Lisa ;

Huidekoper, Hidde H. ;

Vaz, Frederic M. ;

Singh, Renu ;

Steiner, Robert D. ;

DeBarber, Andrea E. .

MOLECULAR GENETICS AND METABOLISM REPORTS, 2016, 7 :11-15

← 1 2 3 4 5 6 7 8 9 →