Abatacept in B7-1-Positive Proteinuric Kidney Disease

被引：281

作者：

Yu, Chih-Chuan ^{[1
,2
,5
]}

Fornoni, Alessia ^{[7
]}

Weins, Astrid ^{[1
,2
,3
]}

Hakroush, Samy ^{[1
,2
]}

Maiguel, Dony ^{[1
,7
]}

Sageshima, Junichiro ^{[8
]}

Chen, Linda ^{[8
]}

Ciancio, Gaetano ^{[8
]}

Faridi, Mohd Hafeez ^{[7
]}

Behr, Daniel ^{[2
]}

Campbell, Kirk N. ^{[9
]}

Chang, Jer-Ming ^{[6
]}

Chen, Hung-Chun ^{[6
]}

Oh, Jun ^{[10
]}

Faul, Christian ^{[7
]}

Arnaout, M. Amin ^{[1
,2
]}

Fiorina, Paolo ^{[4
]}

Gupta, Vineet ^{[7
]}

Greka, Anna ^{[1
,2
]}

Burke, George W., III ^{[8
]}

Mundel, Peter ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[4] Childrens Hosp, Div Nephrol, Boston, MA 02115 USA

[5] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan

[6] Kaohsiung Med Univ, Coll Med, Dept Internal Med, Kaohsiung, Taiwan

[7] Univ Miami, Miller Sch Med, Div Nephrol & Hypertens, Miami, FL 33136 USA

[8] Univ Miami, Miller Sch Med, Lilian Jean Kaplan Div Kidney Pancreas Transplant, Miami Transplant Inst,Dept Surg, Miami, FL 33136 USA

[9] Mt Sinai Sch Med, Div Nephrol, New York, NY USA

[10] Univ Med Ctr Hamburg Eppendorf, Childrens Hosp, Hamburg, Germany

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2013年 / 369卷 / 25期

基金：

美国国家卫生研究院;

关键词：

RHEUMATOID-ARTHRITIS; INTEGRIN ACTIVATION; PODOCYTES; TALIN;

D O I：

10.1056/NEJMoa1304572

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abatacept (cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin fusion protein [CTLA-4-Ig]) is a costimulatory inhibitor that targets B7-1 (CD80). The present report describes five patients who had focal segmental glomerulosclerosis (FSGS) (four with recurrent FSGS after transplantation and one with primary FSGS) and proteinuria with B7-1 immunostaining of podocytes in kidney-biopsy specimens. Abatacept induced partial or complete remissions of proteinuria in these patients, suggesting that B7-1 may be a useful biomarker for the treatment of some glomerulopathies. Our data indicate that abatacept may stabilize 1-integrin activation in podocytes and reduce proteinuria in patients with B7-1-positive glomerular disease.

引用

页码：2416 / 2423

页数：8

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