Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein

被引：16

作者：

Deprez, P ^{[1
]}

Mandine, E ^{[1
]}

Gofflo, D ^{[1
]}

Meunier, S ^{[1
]}

Lesuisse, D ^{[1
]}

机构：

[1] Aventis Pharma, Paris Res Ctr, Med Chem, F-93235 Romainville, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(02)00140-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Sre SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1295 / 1298

页数：4

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