Water-Soluble Rhamnose-Coated Fe3O4 Nanoparticles

被引：45

作者：

Lartigue, Lenaic ^{[1
,3
]}

Oumzil, Khalid ^{[2
]}

Guari, Yannick ^{[1
]}

Larionova, Joulia ^{[1
]}

Guerin, Christian ^{[1
]}

Montero, Jean-Louis ^{[2
]}

Barragan-Montero, Veronique ^{[2
]}

Sangregorio, Claudio ^{[3
]}

Caneschi, Andrea ^{[3
]}

Innocenti, Claudia ^{[3
]}

Kalaivani, T. ^{[4
,5
]}

Arosio, P. ^{[4
]}

Lascialfari, A. ^{[4
,5
,6
,7
]}

机构：

[1] Univ Montpellier 2, CNRS, UMR 5253, Inst Charles Gerhardt Montpellier,UM2, F-34095 Montpellier 5, France

[2] Ecole Natl Super Chim Montpellier, CNRS, Inst Biomol Mousseron, UMR 5247,UM1,UM2, F-34296 Montpellier, France

[3] Univ Florence, Dipartimento Chim, INSTM Res Unit, I-50019 Sesto Fno Firenze, Italy

[4] Univ Milan, Ist Fisiol Gen & Chim Biol, I-20134 Milan, Italy

[5] CNR, INFM, NRC S3, I-14100 Modena, Italy

[6] Univ Pavia, INFM, CNR, I-27100 Pavia, Italy

[7] Univ Pavia, Dipartimento Fis A Volta, I-27100 Pavia, Italy

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 14期

关键词：

IRON-OXIDE NANOPARTICLES; SUPERPARAMAGNETIC NANOPARTICLES; MAGNETIC NANOPARTICLES; CONTRAST AGENTS; PARTICLES; CANCER; COMPLEXATION;

D O I：

10.1021/ol900949y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Water-soluble biocompatible rhamnose-coated Fe3O4 nanoparticles of 4.0 nm are obtained by covalent anchorage of rhamnose on the nanoparticles surface via a phosphate linker. These nanoparticles present superparamagnetic behavior and nuclear relaxivities in the same order of magnitude as Endorem that make them potential magnetic resonance imaging (MRI) contrast agents of a second generation, where the saccharides represent also specific ligands able to target lectins on skin cells.

引用

页码：2992 / 2995

页数：4

共 37 条

[31] Ultrasmall c(RGDyK)-coated Fe3O4 nanoparticles and their specific targeting to integrin αvβ3-rich tumor cells [J].