An Efficient, Microwave-Assisted, One-Pot Synthesis of Fluorinated 2,5-Disubstituted 1,3,4-Oxdiazole Derivative

被引：2
|
作者：
Dhotre, Bharat K. [1 ]
Patharia, Murtaza A. [2 ]
Raut, Santosh, V [3 ]
Pathan, Mohd Arif [3 ]
机构：
[1] Swami Vivekanand Senior Coll Mantha, Dept Chem, Mantha, Maharashtra, India
[2] NFIL Surat, Navin Res & Innovat Ctr, Surat, India
[3] Maulana Azad Coll Aurangabad, Dept Chem, Aurangabad, Maharashtra, India
来源：
POLYCYCLIC AROMATIC COMPOUNDS | 2021年 / 41卷 / 05期
关键词：
1; 3; 4-oxdiazole; CAN; isoniazid; nicotinic acid hydrazide; microwave irradiation; PEG-400; SOLVENT-FREE SYNTHESIS; HETEROCYCLIC-COMPOUNDS; 1,3,4-OXADIAZOLES; OXADIAZOLES; CATALYST;
D O I：
10.1080/10406638.2019.1635173
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Efficient, rapid, and green procedure has been developed for the synthesis fluorinated 2,5-disubstituted 1,3,4-oxdiazoles using one-pot reaction of isoniazid or nicotic acid hydrazide and different fluorinated acid in the presence of ceric ammonium nitrate in PEG-400 as a solvent under microwave irradiation. The synthesized compounds were characterized by H-1 NMR, C-13 NMR, IR, and mass spectra. The yields are good to excellent, the process is rapid. The protocol was shown to have some advantageous such as short reaction time, low cost, eco-friendly catalyst, and mild reaction conditions.
引用
收藏
页码：974 / 981
页数：8
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