Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides

被引：37

作者：

Fuloria, Neeraj Kumar ^{[1
]}

Singh, Vijender ^{[1
]}

Shaharyar, Mohammad ^{[2
]}

Ali, Mohammad ^{[3
]}

机构：

[1] Rameesh Inst Vocat & Tech Educ, Dept Pharm, Greater Noida, India

[2] Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India

[3] Fac Pharm, Dept Pharmacognosy & Phytochem, New Delhi 110062, India

来源：

MOLECULES | 2009年 / 14卷 / 05期

关键词：

phenylpropionohydrazide; imines; oxadiazoles; antibacterial; antifungal; DERIVATIVES;

D O I：

10.3390/molecules14051898

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study a series of new 1-(2-aryl-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl) ethanones 2a-e was synthesized by the cyclization of imines 1a-e using acetic anhydride. The products were evaluated for anti-bacterial and anti-fungal activity. Among the newly synthesized compounds, 1-(2-(4-(dimethylamino)phenyl)-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2a) and 1-(2-(4-chlorophenyl)-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2b) were found to possess maximum activity against the tested strains of S. aureus and P. aeruginosa. It was concluded that para-substitution enhances the activity of synthesized oxadiazoles.

引用

页码：1898 / 1903

页数：6

共 12 条

[1] Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties [J].

Balsamo, A ;

Bertini, S ;

Gervasi, G ;

Lapucci, A ;

Nencetti, S ;

Orlandini, E ;

Rapposelli, S ;

Rossello, A ;

Soldani, G .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2001, 36 (10) :799-808

[2]

CARLOS V, 2005, BIOORGAN MED CHEM, V13, P2749

[3] Antikinetoplastid activity of 3-aryl-5-thiocyanatomethyl-1,2,4-oxadiazoles [J].

Cottrell, DM ;

Capers, J ;

Salem, MM ;

DeLuca-Fradley, K ;

Croft, SL ;

Werbovetz, KA .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (11) :2815-2824

[4]

Fuloria N.K., 2008, S BRAZ J CHEM, V16, P11

[5]

Fuloria NK, 2008, ASIAN J CHEM, V20, P4891

[6]

Fuloria NK, 2008, ASIAN J CHEM, V20, P6457

[7]

Fuloria NK, 2009, ACTA POL PHARM, V66, P141

[8]

HARSANYI K, 1966, ARZNEI-FORSCHUNG, V16, P615

[9] Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a new non-steroidal anti-inflammatory drug, in rats and guinea pigs [J].

Kido, H ;

Murakami, N ;

Ito, A ;

Kimura, K ;

Kodera, N ;

Doi, T ;

Naruse, T .

JAPANESE JOURNAL OF PHARMACOLOGY, 1998, 76 (01) :75-86

[10]

MAZZONE G, 1979, FARMACO-ED SCI, V34, P390

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