Targeting tumor-associated macrophages for cancer immunotherapy

被引：98

作者：

Shu, Yongheng ^{[1
,2
]}

Cheng, Ping ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, 17 Peoples South Rd, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp, Collaborat Innovat Ctr Biotherapy, Canc Ctr, Chengdu 610041, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2020年 / 1874卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Tumor; Immunotherapy; Tumor-associated macrophages (TAMs); HUMAN MONOCLONAL-ANTIBODY; CHEMOKINE LIGAND 2; CARLUMAB CNTO 888; CAR-T-CELLS; ANTITUMOR-ACTIVITY; SIRP-ALPHA; PHASE-I; MYELOID CELLS; RECEPTOR; ACTIVATION;

D O I：

10.1016/j.bbcan.2020.188434

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophages are important effector cells of the innate immune system and are also major components of the tumor microenvironment (TME). Macrophages that are abundant in the TME are called tumor-associated macrophages (TAMs). As TAMs promote strong tumor angiogenesis and support tumor cell survival, they are closely related to tumor growth. Several studies have demonstrated that reducing the density or effects of TAMs can inhibit the growth of tumors, making them targets for cancer immunotherapy, which has become a research hot spot. Several clinical and preclinical trials have studied drugs that inhibit the effects of and reduce the population of phagocytes that target TAMs achieve cancer immunotherapy. In this paper, we summarize the various methods of targeting TAMs for tumor immunotherapy, focusing on TAM mechanisms, sources, and polarization.

引用

页数：11

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