Targeting tumor-associated macrophages for cancer immunotherapy

被引：98

作者：

Shu, Yongheng ^{[1
,2
]}

Cheng, Ping ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, 17 Peoples South Rd, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp, Collaborat Innovat Ctr Biotherapy, Canc Ctr, Chengdu 610041, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2020年 / 1874卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Tumor; Immunotherapy; Tumor-associated macrophages (TAMs); HUMAN MONOCLONAL-ANTIBODY; CHEMOKINE LIGAND 2; CARLUMAB CNTO 888; CAR-T-CELLS; ANTITUMOR-ACTIVITY; SIRP-ALPHA; PHASE-I; MYELOID CELLS; RECEPTOR; ACTIVATION;

D O I：

10.1016/j.bbcan.2020.188434

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophages are important effector cells of the innate immune system and are also major components of the tumor microenvironment (TME). Macrophages that are abundant in the TME are called tumor-associated macrophages (TAMs). As TAMs promote strong tumor angiogenesis and support tumor cell survival, they are closely related to tumor growth. Several studies have demonstrated that reducing the density or effects of TAMs can inhibit the growth of tumors, making them targets for cancer immunotherapy, which has become a research hot spot. Several clinical and preclinical trials have studied drugs that inhibit the effects of and reduce the population of phagocytes that target TAMs achieve cancer immunotherapy. In this paper, we summarize the various methods of targeting TAMs for tumor immunotherapy, focusing on TAM mechanisms, sources, and polarization.

引用

页数：11

共 123 条

[21] Contribution of metabolic reprogramming to macrophage plasticity and function [J].

El Kasmi, Karim C. ;

Stenmark, Kurt R. .

SEMINARS IN IMMUNOLOGY, 2015, 27 (04) :267-275

[22] The Adenosine-Dependent Angiogenic Switch of Macrophages to an M2-Like Phenotype is Independent of Interleukin-4 Receptor Alpha (IL-4Rα) Signaling [J].

Ferrante, Christopher James ;

Pinhal-Enfield, Grace ;

Elson, Genie ;

Cronstein, Bruce Neil ;

Hasko, Gyorgy ;

Outram, Shalini ;

Leibovich, Samuel Joseph .

INFLAMMATION, 2013, 36 (04) :921-931

[23] Implications of macrophage polarization in autoimmunity [J].

Funes, Samanta C. ;

Rios, Mariana ;

Escobar-Vera, Jorge ;

Kalergis, Alexis M. .

IMMUNOLOGY, 2018, 154 (02) :186-195

[24] Thymosin α1 and cancer: action on immune effector and tumor target cells [J].

Garaci, Enrico ;

Pica, Francesca ;

Serafino, Annalucia ;

Balestrieri, Emanuela ;

Matteucci, Claudia ;

Moroni, Gabriella ;

Sorrentino, Roberta ;

Zonfrillo, Manuela ;

Pierimarchi, Pasquale ;

Sinibaldi-Vallebona, Paola .

THYMOSINS IN HEALTH AND DISEASE I, 2012, 1269 :26-33

[25] Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis [J].

Georgoudaki, Anna-Maria ;

Prokopec, Kajsa E. ;

Boura, Vanessa F. ;

Hellqvist, Eva ;

Sohn, Silke ;

Ostling, Jeanette ;

Dahan, Rony ;

Harris, Robert A. ;

Rantalainen, Mattias ;

Klevebring, Daniel ;

Sund, Malin ;

Brage, Suzanne Egyhazi ;

Fuxe, Jonas ;

Rolny, Charlotte ;

Li, Fubin ;

Ravetch, Jeffrey V. ;

Karlsson, Mikael C. I. .

CELL REPORTS, 2016, 15 (09) :2000-2011

[26] Role of Macrophage Targeting in the Antitumor Activity of Trabectedin [J].

Germano, Giovanni ;

Frapolli, Roberta ;

Belgiovine, Cristina ;

Anselmo, Achille ;

Pesce, Samantha ;

Liguori, Manuela ;

Erba, Eugenio ;

Uboldi, Sarah ;

Zucchetti, Massimo ;

Pasqualini, Fabio ;

Nebuloni, Manuela ;

van Rooijen, Nico ;

Mortarini, Roberta ;

Beltrame, Luca ;

Marchini, Sergio ;

Nerini, Ilaria Fuso ;

Sanfilippo, Roberta ;

Casali, Paolo G. ;

Pilotti, Silvana ;

Galmarini, Carlos M. ;

Anichini, Andrea ;

Mantovani, Alberto ;

D'Incalci, Maurizio ;

Allavena, Paola .

CANCER CELL, 2013, 23 (02) :249-262

[27] Phase I study of emactuzumab single agent or in combination with paclitaxel in patients with advanced/metastatic solid tumors reveals depletion of immunosuppressive M2-like macrophages [J].

Gomez-Roca, C. A. ;

Italiano, A. ;

Le Tourneau, C. ;

Cassier, P. A. ;

Toulmonde, M. ;

D'Angelo, S. P. ;

Campone, M. ;

Weber, K. L. ;

Loirat, D. ;

Cannarile, M. A. ;

Jegg, A-M ;

Ries, C. ;

Christen, R. ;

Meneses-Lorente, G. ;

Jacob, W. ;

Klaman, I ;

Ooi, C-H ;

Watson, C. ;

Wonde, K. ;

Reis, B. ;

Michielin, F. ;

Ruettinger, D. ;

Delord, J-P ;

Blay, J-Y .

ANNALS OF ONCOLOGY, 2019, 30 (08) :1381-1392

[28] Alternative Activation of Macrophages: Mechanism and Functions [J].

Gordon, Siamon ;

Martinez, Fernando O. .

IMMUNITY, 2010, 32 (05) :593-604

[29] PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity [J].

Gordon, Sydney R. ;

Aute, Roy L. M. ;

Dulken, Ben W. ;

Hutter, Gregor ;

George, Benson M. . ;

Ccracken, Melissa N. M. ;

Gupta, Rohit ;

Tsai, Jonathan M. . ;

Sinha, Rahul ;

Corey, Daniel ;

Ring, Aaron M. . ;

Connolly, Andrew J. ;

Weissman, Irving L. .

NATURE, 2017, 545 (7655) :495-+

[30] Co-engaging CD47 and CD19 with a bispecific antibody abrogates B-cell receptor/CD19 association leading to impaired B-cell proliferation [J].

Hatterer, Eric ;

Barba, Leticia ;

Noraz, Nelly ;

Daubeuf, Bruno ;

Aubry-Lachainaye, Jean-Pierre ;

von der Weid, Benoit ;

Richard, Francoise ;

Kosco-Vilbois, Marie ;

Ferlin, Walter ;

Shang, Limin ;

Buatois, Vanessa .

MABS, 2019, 11 (02) :322-334

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