Amelioration of cold-induced gastric injury by a yeast probiotic isolated from traditional fermented foods

被引：33

作者：

Banik, Abhijit ^{[1
,2
]}

Mondal, Joy ^{[1
]}

Rakshit, Subham ^{[1
]}

Ghosh, Kuntal ^{[3
]}

Sha, Shankar Prasad ^{[4
]}

Halder, Suman Kumar ^{[1
]}

Ghosh, Chandradipa ^{[2
]}

Mondal, Keshab Chandra ^{[1
]}

机构：

[1] Vidyasagar Univ, Dept Microbiol, Midnapore 721102, W Bengal, India

[2] Vidyasagar Univ, Dept Human Physiol Community Hlth, Midnapore 721102, W Bengal, India

[3] Midnapore City Coll, Dept Biol Sci, Paschim Medinipur 721129, W Bengal, India

[4] Sikkim Univ, Sch Life Sci, Dept Microbiol, Gangtok 737102, Sikkim, India

来源：

JOURNAL OF FUNCTIONAL FOODS | 2019年 / 59卷

关键词：

Saccharomyces cerevisiae; Probiotic; Anti-ulcerative; Anti-inflammatory; ADHESION; STRAINS; MILK;

D O I：

10.1016/j.jff.2019.05.039

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

In this study, an isolated yeast strain AKP1 was selected (out of 10 isolates) on the basis of the cumulative probiotic score. Genotypic characterization confirmed that it was a Saccharomyces cerevisiae. Gastroprotective effect of AKP1 was evaluated by cold-induced gastric ulcer model in rats. Prior supplementation of AKP1 along with the food led to significant reduction of the cold-induced gastric lesion in stomach. The histological study clearly showed that the mucosal columnar epithelial cells of the stomach were protected from cold injury. The relative expressions of some inflammatory marker genes such as up-regulation of IL-10 and down-regulation of IL-12, IFN-gamma, IFN-lambda. of gastric mucosa also supported the anti-inflammatory activity of AKP1. Therefore, the newly isolated yeast strain Saccharomyces cerevisiae AKP1 might be a novel candidate of probiotic with an anti-ulcerogenic potential and can be used as a therapeutic component to prevent this widespread disease.

引用

页码：164 / 173

页数：10

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