C4-Alkylamination of C4-Halo-1H-1-tritylpyrazoles Using Pd(dba)2 or CuI

被引：8

作者：

Usami, Yoshihide ^{[1
]}

Tatsui, Yuya ^{[1
]}

Yoneyama, Hiroki ^{[1
]}

Harusawa, Shinya ^{[1
]}

机构：

[1] Osaka Univ Pharmaceut Sci, Dept Organ Pharmaceut Chem, 4-20-1 Nasahara, Takatsuki, Osaka 5691094, Japan

来源：

MOLECULES | 2020年 / 25卷 / 20期

关键词：

amination; 4-halopyrazole; Buchwald-Hartwig coupling; Pd(dba)(2); CuI mediated coupling; aliphatic amine; CROSS-COUPLING REACTION; CATALYZED AMINATION; ARYL HALIDES; INHIBITORS; RING; LEAD;

D O I：

10.3390/molecules25204634

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alkylamino coupling reactions at the C4 positions of 4-halo-1H-1-tritylpyrazoles were investigated using palladium or copper catalysts. The Pd(dba)(2) catalyzed C-N coupling reaction of aryl- or alkylamines, lacking a beta-hydrogen atom, proceeded smoothly using (t)BuDavePhos as a ligand. As a substrate, 4-Bromo-1-tritylpyrazole was more effective than 4-iodo or chloro-1-tritylpyrazoles. Meanwhile, the CuI mediated C-N coupling reactions of 4-iodo-1H-1-tritylpyrazole were effective for alkylamines possessing a beta-hydrogen atom.

引用

页数：12

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