Multiple Sites of Insecticidal Action in Ionotropic GABA Receptors

被引：0

作者：

Ozoe, Yoshihisa ^{[1
,2
]}

Ozoe, Fumiyo ^{[1
]}

Kita, Tomo ^{[2
]}

Rahman, Mohammad Mostafizur ^{[2
]}

Liu, Genyan ^{[2
]}

Hisano, Kazutoshi ^{[1
]}

Takashima, Madoka ^{[1
]}

Nakata, Yunosuke ^{[1
]}

机构：

[1] Shimane Univ, Fac Life & Environm Sci, Dept Life Sci & Biotechnol, Matsue, Shimane 6908504, Japan

[2] Tottori Univ, United Grad Sch Agr Sci, Div Biosci & Biotechnol, Tottori 6808553, Japan

来源：

DISCOVERY AND SYNTHESIS OF CROP PROTECTION PRODUCTS | 2015年 / 1204卷

关键词：

GAMMA-AMINOBUTYRIC-ACID; META-DIAMIDE INSECTICIDES; GATED CHLORIDE CHANNELS; AMINO-ACID; BINDING; RESISTANCE; IDENTIFICATION; SELECTIVITY; ANTAGONISTS; MUTATIONS;

D O I：

暂无

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

Pentameric ligand-gated ion channels (LGICs) of insects are among the targets of existing insecticides. Given the presence of multiple ligand-binding sites and the allostery in LGICs, more studies could provide further opportunities for insecticide discovery. Ionotropic gamma-aminobutyric acid (GABA) receptors (GABARs) fall into the family of LGICs, and insect GABARs are insecticidal targets of fipronil, a conventional noncompetitive antagonist (cNCA), and of isoxazolines and benzamides, which are a novel type of NCAs and have a different site(s) of action from that of cNCAs. The mechanism of interaction of competitive antagonists with the orthosteric site merits further investigation for developing novel insecticidal compounds.

引用

页码：431 / 446

页数：16

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