Codeine intoxication in the neonate

被引：18

作者：

Magnani, B

Evans, R

机构：

[1] Boston Univ, Boston Med Ctr, Sch Med, Dept Pathol & Lab Med, Boston, MA USA

[2] Off Chief Med Examiner Commonwealth Massachusetts, Boston, MA USA

来源：

PEDIATRICS | 1999年 / 104卷 / 06期

关键词：

codeine; neonate; toxicity; morphine; fatality;

D O I：

10.1542/peds.104.6.e75

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Although opiates can provide patients with relief from pain and the discomfort of cough, the routine prescription of these drugs for infants demands caution and concern. Infants, particularly neonates, are not merely small adults requiring smaller dosages, but rather uniquely different patients. Neonates present with an immature physiology and biochemistry with respect to drug metabolism. We report a case of codeine intoxication in the neonate, in which the drug was prescribed for cough control during an emergency department visit.

引用

页数：3

共 19 条

[1]

ANDERSON WH, 1989, ADV ANAL TOXICOLOGY, P70

[2]

BASELT RC, 1995, DIPOSITION TOXIC DRU, P191

[3] PRINCIPLES OF DRUG BIODISPOSITION IN THE NEONATE - A CRITICAL-EVALUATION OF THE PHARMACOKINETIC-PHARMACODYNAMIC INTERFACE .1. [J].