Self-assembly of bi-functional peptides on large-pore mesoporous silica nanoparticles for miRNA binding and delivery

被引：21

作者：

Lu, Jingxiong ^{[1
]}

Shen, Hsin-Hui ^{[2
]}

Wu, Zhangxiong ^{[3
]}

Wang, Bo ^{[4
]}

Zhao, Dongyuan ^{[1
,5
,6
]}

He, Lizhong ^{[1
]}

机构：

[1] Monash Univ, Dept Chem Engn, Melbourne, Vic 3800, Australia

[2] Monash Univ, Dept Microbiol, Melbourne, Vic 3800, Australia

[3] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Jiangsu, Peoples R China

[4] Monash Univ, Dept Anat & Dev Biol, Melbourne, Vic 3800, Australia

[5] Fudan Univ, Shanghai Key Lab Mol Catalysis & Innovat Mat, Dept Chem, Shanghai 200433, Peoples R China

[6] Fudan Univ, Adv Mat Lab, Shanghai 200433, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2015年 / 3卷 / 39期

关键词：

MEDIATED SIRNA DELIVERY; IN-VIVO; GENE DELIVERY; LIPID NANOPARTICLES; ENDOSOMAL ESCAPE; CELLULAR UPTAKE; INTERFERENCE; RNA; ADSORPTION; EFFICIENCY;

D O I：

10.1039/c5tb01133g

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Bi-functional peptides were designed to have binding abilities for both silica nanoparticles and miRNAs. Non-covalent self-assembly of peptides on large pore mesoporous silica nanoparticles provides a delivery system that shows a high binding capacity for nucleic acids, strong transfection efficiency of miRNA and attractive down-regulation of protein expression.

引用

页码：7653 / 7657

页数：5

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