Diagnosis and classification of autoimmune parathyroid disease

被引：25
作者：
Betterle, Corrado [1 ]
Garelli, Silvia [1 ]
Presotto, Fabio [2 ]
机构：
[1] Univ Padua, Endocrine Unit, Dept Med, I-35128 Padua, Italy
[2] Mestre Venice Osped Angelo, Internal Med Unit, I-30174 Venice, Italy
来源：
AUTOIMMUNITY REVIEWS | 2014年 / 13卷 / 4-5期
关键词：
Autoimmune hypoparathyroidism; Chronic hypoparathyroidism; Autoimmune polyendocrine syndromes; NACHT leucine-rich-repeat protein 5 autoantibodies; Calcium-sensing receptor autoantibodies; CALCIUM-SENSING RECEPTOR; POLYENDOCRINE SYNDROME TYPE-1; SPORADIC IDIOPATHIC HYPOPARATHYROIDISM; ACQUIRED HYPOCALCIURIC HYPERCALCEMIA; SYNDROME TYPE-I; ADDISONS-DISEASE; AIRE GENE; AUTOANTIBODIES; CANDIDIASIS; PREVALENCE;
D O I：
10.1016/j.autrev.2014.01.044
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hypoparathyroidism (HP) is clinically characterized by the presence of hypocalcemia, usually associated with specific signs and symptoms that depend on how severe and chronic the disease becomes. HP is usually caused by surgical removal of all four parathyroids, while other forms are rarer. Autoimmune HP can occur as an isolated disease or as part of an autoimmune polyendocrine syndrome. Here we review what is known about parathyroid gland autoimmunity, focusing on recently-proposed parathyroid autoantibody markers, and particularly those directed against NACHT leucine-rich-repeat protein 5 and calcium-sensing receptor. We also describe the clinical characteristics of HP and design a diagnostic algorithm for autoimmune HP. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：417 / 422
页数：6
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