A Convenient Synthesis of New Pyrazolo[4,3-d]pyrimidines and Their Fused Heterocycles

被引：12

作者：

Rote, Ramhari V. ^{[1
]}

Shelar, Deepak P. ^{[1
]}

Patil, Sandeep R. ^{[1
]}

Jachak, Madhukar N. ^{[1
]}

机构：

[1] Univ Pune, KTHM Coll, Organ Chem Res Ctr, Dept Chem, Nasik 422002, Maharashtra, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2014年 / 51卷 / 03期

关键词：

POTENTIAL PURINE ANTAGONISTS; ADENOSINE RECEPTOR ANTAGONISTS; PYRAZOLO-TRIAZOLO-PYRIMIDINE; CROSS-COUPLING REACTION; PYRAZOLO<3,4-D>PYRIMIDINES; 1-ALKENYLBORANES; DERIVATIVES;

D O I：

10.1002/jhet.2006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of some fused heterocycles originated from pyrazolopyrimidines were synthesized using 4-amino1-methyl-3-propyl-1H-pyrazole-5-carboxamide as a starting material. The nucleophilic substitution reactions with different amino acids followed by cyclization and Suzuki-Miyaura cross-coupling reactions with different aryl boronic acids of 7-chloro-5-(4-chlorophenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine were performed. Also, the oxidative cyclization reactions of 1-(5-(4-chlorophenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)hydrazine with different aldehydes in the presence of diacetoxy iodobenzene are described. All the synthesized compounds were characterized by analytical and spectroscopic methods.

引用

页码：815 / 823

页数：9

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